An in vitro study of the activity of telithromycin against mobile and cystic forms of Borrelia afzelii

Infection
Ø Brorson, S-H Brorson

Abstract

In this study the new ketolide telithromycin was tested in vitro against motile and cystic forms of Borrelia afzelii, one of the species of Borrelia burgdorferi sensu lato. Acridine orange staining, dark field microscopy, and transmission electron microscopy were the techniques used to study the influence of telithromycin on the bacteria. The activity was unexpectedly high, 0.0003 microg/ml < MBC < or = 0.0006 microg/ml for the mobile forms after 7 days of incubation at 34 degrees C. MIC was < 0.00015 microg/ml. It is likely that the agent works bacteriostatically and kills in a time-dependent and concentration-independent way, by binding tightly to the ribosomes. The agent was not able to prevent cyst formation, and the cysts were not affect ed at an in vivo achievable concentration. Electron microscopy also supports the hypothesis of telithromycin being an effective agent against the mobile bacteria.

Citations

Jun 23, 2011·Infection and Drug Resistance·Raphael B Stricker, Lorraine Johnson
Mar 18, 2008·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Michal KrupkaEvzen Weigl
Oct 19, 2012·Future Microbiology·Raphael B Stricker, Lorraine Johnson
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul M LantosGary P Wormser

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