PMID: 38316Jul 1, 1979

An in vitro study of the effects of calcium on the cardiovascular actions of thiopentone, althesin and ketamine in the rat

The Journal of Pharmacy and Pharmacology
P J Hall, B J Pleuvry


The actions of three intravenous anaesthetics, Althesin, thiopentone and ketamine have been compared on the rat isolated atria and portal vein. Although the three anaesthetics had grossly similar actions on the two preparations. i.e. depression of atrial rate and depression of the amplitude of myogenic activity in the portal vein, there were enough differences to suggest that they produced their effects by different mechanisms. These differences were particularly obvious in interactions with noradrenaline and the effects of changes in calcium ion concentration on the concentration effect relationships for the agents on the atria and portal vein. Generally Althesin was unaffected by changes, but in qualitatively different ways.



Jan 1, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·V A KreyeH Schmidt-Gayk
Sep 1, 1977·Neurology·M A Goldberg
Aug 1, 1977·British Journal of Anaesthesia·P KraunakJ M Rees
Sep 1, 1976·Anaesthesia·M Johnstone
Feb 1, 1972·The American Journal of Physiology·W G Nayler, J Szeto
Jul 1, 1974·Postgraduate Medical Journal·W G Nayler, D Krikler
Jan 1, 1973·The Tohoku Journal of Experimental Medicine·N Iwatsuki
Jul 1, 1971·British Journal of Anaesthesia·T M SavageB R Simpson

Related Concepts

Myocardial Contraction
Calcium [EPC]
Entire Portal Vein
Entire Trunk of Portal Vein
Portal Vein Structure
Calcium ion
Norepinephrine, (+, -)-Isomer
Right Atrial Structure
Structure of Trunk of Portal Vein

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