An in vitro study on reproductive toxicology of Deltamethrin on rat spermatozoa

Andrologia
Fatma Ben AbdallahL Keskes-Ammar

Abstract

Recent findings indicate that synthetic pyrethroid insecticide may induce toxic manifestations by enhancing the production of reactive oxygen species and disrupting the balance between pro-oxidants and antioxidants as a result of lipid peroxidation (LP) of cell membranes. The aim of the study was to examine the potency of Deltamethrin (Del) to induce oxidative stress response in rat spermatozoa in vitro. Spermatozoa were incubated with different concentrations (0, 10, 50, 100 and 200 microm) of Del for 3 h at 37 degrees C. After that, sperm parameters (motility, viability and abnormal morphology), malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels were determined. We found that in vitro exposure to Del caused a significant decline of sperm motility and viability and increase of abnormal sperm morphology, MDA, SOD and CAT levels at different concentrations of Del. This study demonstrated that Del caused deterioration in sperm motility and viability, and induction in LP, abnormal morphology of spermatozoa and antioxidants enzyme activities.

References

Nov 1, 1977·Fertility and Sterility·R Eliasson
Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Jul 1, 1989·Biology of Reproduction·R J AitkenS Fishel
Jan 1, 1984·Methods in Enzymology·H Aebi
Jan 1, 1984·Methods in Enzymology·K Yagi
Jul 22, 1999·Toxicology Letters·B D BanerjeeA K Chakraborty
Oct 13, 2001·Archives of Environmental Contamination and Toxicology·A ElbetiehaH Darmani
Dec 17, 2003·Pharmacology & Toxicology·Göksel SenerGül Ayanoglu-Dülger

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Citations

Sep 15, 2014·The Science of the Total Environment·Josep Anton Mir-TutusausCarlos E Rodríguez-Rodríguez
Nov 21, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·R S TavaresJ Ramalho-Santos
May 12, 2016·Human & Experimental Toxicology·A Ben SlimaR Gdoura
May 23, 2013·Polish Journal of Veterinary Sciences·Z Siroka, Z Svobodova
Nov 27, 2020·Environmental Science and Pollution Research International·Muhammet Yasin TekeliZeynep Soyer Sarıca
Mar 17, 2021·Toxicology and Industrial Health·Mingqing ZhongYuanyuan Li

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