An in vivo biocompatibility study of surgical meshes made from bacterial cellulose modified with chitosan

International Journal of Biological Macromolecules
Joanna Piasecka-ZelgaDanuta Ciechańska

Abstract

Bacterial cellulose modified with chitosan (MBC) is an innovative biomaterial used in regenerative medicine which may potentially improve treatment outcomes mesh for hernia repair surgery by facilitating better absorption in native tissue with less risk of mesh-related infections. The aim of the present study was to evaluate the biocompatibility of mesh based on MBC, and determine whether immunological reactions occur due to hypersensitivity to the implants. Forty five Imp:WIST rats were randomly assigned to be implanted with one of three mesh types: simple polypropylene mesh (n = 15), mesh modified by bacterial cellulose only (n = 15) and MBC mesh (n = 15) and evaluated after one and three months following intramuscular implantation. For MBC mesh, basic toxicological studies, i.e. Acute Dermal Irritation, Intradermal Reactivity and Acute Sensitization (GPMT), were also carried out on 9 Imp:BN albino rabbits and 15 Imp:D-H guinea pigs. The lowest immune response and the highest degree of fibroplasia were observed for MBC mesh both after one and three months after implantation. Toxicological studies classified the tested MBC mesh as a barely perceptible irritant with no signs of sensitization or allergic reactions observed durin...Continue Reading

Citations

Sep 13, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Siriwan SrisangNorased Nasongkla
Mar 7, 2019·Microbial Biotechnology·Raquel PortelaRita G Sobral
Sep 25, 2019·Nanomaterials·Selestina Gorgieva, Janja Trček
Oct 1, 2020·Bioactive Materials·Wenbo LiuHaoye Meng
Mar 13, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Mahboubeh BouhlouliArash Khojasteh
Mar 10, 2020·ACS Nano·Patrick A RühsPhillip B Messersmith
Sep 9, 2021·ACS Applied Materials & Interfaces·Jaehwan Kim, Jinho Hyun
Nov 19, 2021·Biotechnology & Genetic Engineering Reviews·Elahe Vadaye KheiryMohammad Amin Kerachian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
James D Perkins
The European Journal of Surgery = Acta Chirurgica
U KlingeV Schumpelick
© 2022 Meta ULC. All rights reserved