PMID: 9184932Apr 1, 1997Paper

An in vivo dose-response study of fenbendazole against Oesophagostomum dentatum and Oesophagostomum quadrispinulatum in pigs

International Journal for Parasitology
J PraslickaH Talvik

Abstract

A dose-response study using fenbendazole (FBZ) was carried out in pigs infected with O. dentatum and O. quadrispinulatum to determine the minimum effective dose rate of the drug. Thirty pigs were randomly divided into 6 groups of 5 pigs and infected with 5000 infective larvae each. The animals were re-infected 5 days before treatment (Day 30 after the first infection) with the same number of larvae. On Day 35 the pigs in groups 1-5 were treated with FBZ at the following dose rates: 2.5 mg kg-1 (i.e. 50% of the registered dose level), 1.0 mg kg-1 (20%), 0.25 mg kg-1 (5%), 0.1 mg kg-1 (2%) and 0.05 mg kg-1 (1%), respectively. Pigs in group 6 served as non-treated controls. Seven days after treatment (Day 42 after infection) the pigs were slaughtered, worms recovered from the large intestine and counted. The species and sex of adult worms was determined. A high faecal egg count reduction (FECR) after treatment was observed in groups 1, 2 and 3 (98%, 88% and 91%, respectively), while in groups 4 and 5 the egg counts were not affected by treatment. The mean worm count reduction was high in groups 1, 2 and 3 (100%, 99.9% and 98.6%, respectively), but declined in groups 4 and 5 (77% and 40%, respectively). FBZ showed a high efficacy a...Continue Reading

References

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Citations

Feb 19, 1998·International Journal for Parasitology·J PraslickaD R Hennessy
Jun 10, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·José L AriasMa Adolfina Ruiz
Sep 4, 2021·Veterinary Parasitology : Regional Studies and Reports·Emelie PetterssonJohan Höglund

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