PMID: 11323131Apr 27, 2001Paper

An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system

Pain
V LimmrothM C Michel

Abstract

Calcitonin gene related peptide (CGRP) released from the C-fibers projecting from the trigeminal ganglion to the meninges has been suggested to play a crucial role in the pathophysiology of headache, particularly migraine. In humans it has been shown that CGRP is released during migraine-attacks, and this is attenuated by the administration of typical anti-migraine drugs such as dihydroergotamine or sumatriptan. We describe a new rat model which allows the study of CGRP release from the meninges into venous blood following activation of the trigeminal vascular system. The effects of classical and new anti-migraine drugs such as acetylsalicylic acid (ASA), sumatriptan and the new high efficacy 5-HT1B/1D agonist donitriptan (4-[4-[2-(2-aminoethyl)-1H-indol-5-yloxyl]acetyl]piperazinyl-1-yl]benzonitrile) were evaluated in comparison with the established model of neurogenic inflammation in the meninges. Sumatriptan and donitriptan inhibited CGRP release as well as neurogenic inflammation. ASA, however, attenuated neurogenic inflammation, but not CGRP release, confirming the concept of prejunctional inhibition of CGRP release by 5-HT1B/1D receptors. This new model allows the further study of prejunctional pharmacology and mechanisms ...Continue Reading

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Citations

Oct 9, 2002·Pharmazie in unserer Zeit·Volker Limmroth
Oct 9, 2002·Pharmazie in unserer Zeit·Andreas Link, Britta Link
Nov 18, 2011·Current Treatment Options in Neurology·Jan Hoffmann, Peter J Goadsby
Nov 14, 2003·Brain Research. Brain Research Protocols·Sigrid Schuh-HoferUlrich Dirnagl
Sep 22, 2006·The Clinical Journal of Pain·Akifumi KanaiSumio Hoka
Aug 19, 2004·Cephalalgia : an International Journal of Headache·U ArulmaniP R Saxena
Feb 4, 2005·Cephalalgia : an International Journal of Headache·N OffenhauserU Reuter
Jan 7, 2006·Cephalalgia : an International Journal of Headache·T ZinckI Jansen-Olesen
Jun 19, 2008·Cephalalgia : an International Journal of Headache·A M Harriott, M S Gold
Jun 30, 2009·Cephalalgia : an International Journal of Headache·J HoffmannU Reuter
Apr 29, 2006·Headache·Akifumi KanaiSumio Hoka
Sep 18, 2007·Expert Review of Neurotherapeutics·Heinz G EndresAlbrecht Molsberger
Aug 25, 2015·Journal of Neural Transmission·Zsuzsanna BohárÁrpád Párdutz
Sep 2, 2008·Expert Review of Neurotherapeutics·Ivano FarinelliPaolo Martelletti
Feb 22, 2011·Autonomic Neuroscience : Basic & Clinical·Junchao WeiQi Wan
Nov 17, 2012·Cephalalgia : an International Journal of Headache·Deepak K BhattJes Olesen
Jun 2, 2012·Cephalalgia : an International Journal of Headache·Jan HoffmannUwe Reuter
Mar 14, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Yi ZhangYuan Chen
Aug 30, 2019·The Journal of Headache and Pain·Andrea M HarriottPhilip R Holland
Jan 25, 2017·BioMed Research International·Abimael González-HernándezCarlos M Villalón
Oct 25, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Kelly L RogersLyn R Griffiths
Oct 26, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rosaria GrecoCristina Tassorelli
Oct 29, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Hung-Ruei TzengLih-Chu Chiou

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