An in vivo study of hydrogels based on physiologically clotted fibrin-gelatin composites as wound-dressing materials

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
S E Noorjahan, T P Sastry

Abstract

In this study we have reported the efficacy of three biomaterials: (a) physiologically clotted fibrin-gelatin composite (PFG), (b) PFG graft copolymerized with 2-hydroxyethyl methacrylate (PFG-HEMA), and (c) PFG graft copolymerized with 2-hydroxypropyl methacrylate (PFG-HPMA) as temporary wound-dressing materials using the rat as an animal model. Full-thickness excision wounds were made on the back of female rats weighing about 150 +/- 10 g. The dressings were applied on the wounds and changed periodically at an interval of 4 days with the respective materials. The wounds treated with PFG-HEMA healed completely on 15th day after wound creation, whereas those treated with PFG and PFG-HPMA resulted in complete healing on the 17th day. The concentrations of collagen, hexosamine, and uronic acid in the granulation tissue were determined. The PFG and its graft copolymers acted as hydrogels, thereby absorbing excess exudates, while still maintaining a moist environment at the wound site. The enhanced wound healing in the experimental animals was reflected in the increased rate of wound contraction. The results of the histological and mechanical studies of the experimental groups revealed that reepithelialization and remodeling of the...Continue Reading

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Citations

Aug 2, 2011·Journal of Materials Science. Materials in Medicine·Rose Ann FrancoByong-Taek Lee
Sep 28, 2012·Journal of Materials Science. Materials in Medicine·V RamnathT P Sastry
Oct 23, 2012·Tissue Engineering. Part a·Tírcia C SantosMartijn van Griensven
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Sivakumar SingaraveluUma Tiruchirapalli Sivagnanam
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·S Ali PoursamarA P M Antunes
Nov 15, 2014·Archives of Plastic Surgery·Elijah Zhengyang CaiThiam Chye Lim
Jan 12, 2013·Cells, Tissues, Organs·Pornanong AramwitJuthamas Ratanavaraporn
Jun 23, 2010·Journal of Biomaterials Science. Polymer Edition·Mohammad SirousazarZuhair Muhammad Hassan
Jan 25, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tzu-Wei WangFeng-Huei Lin
Oct 8, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hui MengXiaojun Zhao
Jul 23, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·S E Noorjahan, T P Sastry
Jan 14, 2020·Tissue Engineering. Part B, Reviews·Roel C Op 't VeldFrank A D T G Wagener
Jun 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sivakumar SingaraveluUma Tiruchirapalli Sivagnanam
Apr 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Abhishek MandalThotapalli P Sastry

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