An in vivo study of nanorod, nanosphere, and nanowire forms of titanium dioxide using Drosophila melanogaster: toxicity, cellular uptake, oxidative stress, and DNA damage.

Journal of Toxicology and Environmental Health. Part a
Eşref Demir

Abstract

The biological impact of nanomaterials (NMs) is determined by several factors such as size and shape, which need to be taken into consideration in any type of analysis. While investigators often prefer to conduct in vitro studies for detection of any possible adverse effects of NMs, in vivo approaches yield more relevant data for risk assessment. For this reason, Drosophila melanogaster was selected as a suitable in vivo model to characterize the potential risks associated with exposure nanorods (NRs), nanospheres (NSs), nanowires (NWs) forms of titanium dioxide (TiO2), and their microparticulated (or bulk) form, as TiO2. Third instar larvae (72 hr old larvae) were fed with TiO2 (NRs, NSs, or NWs) and TiO2 at concentrations ranging from 0.01 to 10 mM. Viability (toxicity), internalization (cellular uptake), intracellular reactive oxygen species (ROS) production, and genotoxicity (Comet assay) were the end-points evaluated in hemocyte D. melanogaster larvae. Significant intracellular oxidative stress and genotoxicity were noted at the highest exposure concentration (10 mM) of TiO2 (NRs, NSs, or NWs), as determined by the Comet assay and ROS analysis, respectively. A concentration-effect relationship was observed in hemocytes exp...Continue Reading

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Citations

Sep 25, 2020·Nanotoxicology·Eşref Demir
Oct 29, 2020·Journal of Applied Toxicology : JAT·Eşref Demir
Dec 31, 2020·Journal of Toxicology and Environmental Health. Part a·Orawan KhantamatPiya Temviriyanukul
Mar 13, 2021·Frontiers in Chemistry·Ajita JindalAftab Alam
Apr 21, 2021·Journal of Toxicology and Environmental Health. Part a·Eşref Demir
Jan 14, 2022·Journal of Toxicology and Environmental Health. Part a·Fatma Turna Demir

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Methods Mentioned

BETA
biosensors
transmission
dynamic light scattering
transmission electron microscopy

Software Mentioned

ImageJ
SigmaPlot
SPSS

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