PMID: 11925405Apr 2, 2002Paper

An in-vivo study on placental transfer of naproxen in early human pregnancy

Human Reproduction
S S N SiuT K Lau

Abstract

Naproxen is one of the most common non-steroidal anti-inflammatory drugs used by women of reproductive age. Naproxen is known to be teratogenic in animals. The aim of this study was to investigate the placental transfer of naproxen in the first trimester of human pregnancy, and to determine the amount of the drug in different embryonic compartments. Twenty-eight patients who requested surgical termination of pregnancy in the first trimester were given two oral 500 mg doses of naproxen before the surgical procedure. Four biological samples, maternal venous blood, coelomic fluid, amniotic fluid and fetal tissue, were collected from each patient for drug analyses by high performance liquid chromatography. Naproxen was detected in all samples. The mean (+/- SD) concentrations were 69.5 +/- 12.2 microg/ml, 6.4 +/- 2.4 microg/g, 1.85 +/- 1.03 microg/ml and 0.14 +/- 0.11 microg/ml in maternal serum, fetal tissue, coelomic fluid and amniotic fluid respectively. The mean amniotic fluid/maternal drug ratio and fetal/maternal drug ratio were 0.002 (range 0.0005-0.0064) and 0.092 (range 0.022-0.155) respectively. There was a positive correlation between the fetal drug concentration (r = 0.59, P = 0.001), amniotic fluid drug concentration (...Continue Reading

Citations

Dec 5, 2002·Pharmacoepidemiology and Drug Safety
Apr 6, 2006·Clinical Pharmacokinetics·Shing-Shun N SiuTze-Kin Lau
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Feb 14, 2006·Reproductive Toxicology·Rosy El RamyBrigitte Le Magueresse-Battistoni
Mar 12, 2004·Expert Opinion on Pharmacotherapy·Monika E Østensen, Johan F Skomsvoll
Oct 4, 2005·Obstetrics and Gynecology·Shing-Shun SiuTze Kin Lau
Apr 6, 2013·Anesthesia and Analgesia·Melanie Bloor, Michael Paech
Mar 20, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Alejandro Silva EspinosaIgnacio Briceño Balcazar

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