An inactivated bovine virus diarrhoea virus (BVDV) type 1 vaccine affords clinical protection against BVDV type 2

Vaccine
B MakoscheyP Marel

Abstract

This study was designed to answer to two distinct questions. Firstly, is it possible to reproduce clinical signs of acute bovine virus diarrhoea virus (BVDV) type 2 infection including signs of haemorrhagic disease under experimental conditions in cattle at 20 weeks of age? Secondly, what is the extent of the protection afforded by vaccination with an inactivated BVDV type 1 vaccine against BVDV type 2 infection? Calves were vaccinated at 12 and 16 weeks of age with a commercially available inactivated BVDV type 1 vaccine (Bovilis BVD). At 20 weeks they were challenge infected with BVDV type 2 virus together with unvaccinated control calves. The unvaccinated animals developed typical signs of respiratory disease, diarrhoea with erosions and haemorrhages along the whole length gastro-intestinal tract, and depletion of lymphocytes in lymphatic organs. These signs were either absent or markedly less severe in the vaccinated animals. The beneficial effects of vaccination were most striking in the haematological parameters thrombocytopenia and leukopenia. It can be concluded that vaccination with Bovilis BVD affords cross-protection against clinical effects of a challenge-infection with heterologous type 2 BVDV.

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Citations

Nov 6, 2003·Journal of Virological Methods·C Letellier, P Kerkhofs
Nov 4, 2009·Animal Health Research Reviews·Thomas Passler, Paul H Walz
Dec 18, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·H-R FreyV Moennig
Aug 1, 2007·The Veterinary Quarterly·A T Kalaycioglu
Mar 18, 2006·Comparative Immunology, Microbiology and Infectious Diseases·A J ReberD J Hurley
Sep 3, 2009·Expert Review of Vaccines·Laurel Redding, David B Weiner
Mar 26, 2003·The Journal of Veterinary Medical Science·Tomoaki ShimazakiYoshimitsu Inoue
May 18, 2004·Veterinary Microbiology·D DeregtS V Tessaro
Mar 16, 2004·Veterinary Pathology·U Blas-MachadoS L Caseltine

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