Abstract
A recent study revealed that ES (embryonic stem) cell lines derived from the 129 murine strain carry an inactivating mutation within the caspase 11 gene (Casp4) locus [Kayagaki, Warming, Lamkanfi, Vande Walle, Louie, Dong, Newton, Qu, Liu, Heldens, Zhang, Lee, Roose-Girma and Dixit (2011) Nature 479, 117-121]. Thus, if 129 ES cells are used to target genes closely linked to caspase 11, the resulting mice might also carry the caspase 11 deficiency as a passenger mutation. In the present study, we examined the genetic loci of mice targeted for the closely linked c-IAP (cellular inhibitor of apoptosis) genes, which were generated in 129 ES cells, and found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1(-/-) animals are also deficient in caspase 11. Consequently, data obtained from these mice should be re-evaluated in this new context.
References
Mar 31, 1995·Science·K KuidaR A Flavell
Feb 10, 1995·Cell·P LiJ Salfeld
Aug 23, 1996·The Journal of Biological Chemistry·S WangJ Yuan
May 1, 1997·Nature Genetics·E M SimpsonJ J Sharp
Mar 10, 1998·Cell·S WangJ Yuan
Jan 19, 2000·Nature·T NakagawaJ Yuan
May 3, 2000·The Journal of Cell Biology·S J KangJ Yuan
Sep 17, 2002·Cell Death and Differentiation·S J KangJ Yuan
Mar 31, 2005·Molecular and Cellular Biology·Dietrich B ConzeJonathan D Ashwell
Sep 16, 2005·The EMBO Journal·Anni KleinoMika Rämet
Sep 20, 2005·EMBO Reports·Viola GesellchenMichael Boutros
Dec 31, 2005·Molecular and Cellular Biology·Damiano ConteRobert G Korneluk
Apr 21, 2006·Nature·Maya SalehDonald W Nicholson
Aug 9, 2006·Molecular and Cellular Biology·François LeulierPascal Meier
Oct 28, 2006·The Journal of Biological Chemistry·Jun R HuhBruce A Hay
Mar 9, 2007·Developmental and Comparative Immunology·Susanna ValanneMika Rämet
Sep 11, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Elizabeth D HughesThomas L Saunders
Apr 29, 2008·Molecular Cell·Srinivasa M Srinivasula, Jonathan D Ashwell
Jun 24, 2008·Molecular Cell·Mathieu J M BertrandPhilip A Barker
Aug 8, 2008·The Biochemical Journal·Julie M RumbleColin S Duckett
Oct 15, 2008·The Biochemical Journal·Stefanie GalbánColin S Duckett
May 26, 2009·Immunity·Mathieu J M BertrandMaya Saleh
Oct 5, 2010·Current Opinion in Cell Biology·Juanita Lopez, Pascal Meier
Feb 9, 2011·Blood·Sandra GardamRobert Brink
Feb 19, 2011·Cell Death and Differentiation·M DardingP Meier
Jul 2, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ivana V YangDavid A Schwartz
Oct 18, 2011·Nature·Nobuhiko KayagakiVishva M Dixit
Citations
May 12, 2012·Cell Death and Differentiation·S McCombS Sad
Nov 28, 2012·Human Molecular Genetics·Emeka K EnwereRobert G Korneluk
Jan 8, 2013·International Immunology·Kei YasudaIan R Rifkin
Apr 26, 2013·The Journal of Heredity·Carlos J PerezFernando Benavides
Oct 31, 2012·Molecular and Cellular Biology·Justine T Tigno-AranjuezDerek W Abbott
Jul 3, 2013·American Journal of Respiratory and Critical Care Medicine·Tom Vanden BerghePeter Vandenabeele
Jul 3, 2013·EMBO Molecular Medicine·Rune Busk DamgaardMads Gyrd-Hansen
Nov 21, 2014·Cell Death & Disease·M AzizP Wang
Feb 18, 2016·Immunity·Lorenzo GalluzziGuido Kroemer
Oct 17, 2012·Trends in Immunology·Ian G Rodrigue-Gervais, Maya Saleh
Jul 28, 2012·Trends in Immunology·Shawn T BeugRobert G Korneluk
Jun 4, 2015·Mucosal Immunology·M DagenaisM Saleh
Apr 17, 2015·Immunological Reviews·Irma StoweNobuhiko Kayagaki
Sep 3, 2013·Biochimica Et Biophysica Acta·Kate E Lawlor, James E Vince
Apr 11, 2014·Seminars in Cell & Developmental Biology·Yann Estornes, Mathieu J M Bertrand
Jul 15, 2015·Immunity·Tom Vanden BerghePeter Vandenabeele
Dec 30, 2014·Seminars in Cell & Developmental Biology·John Silke, David L Vaux
Jan 21, 2014·Cell Host & Microbe·Ian Gaël Rodrigue-GervaisMaya Saleh
Apr 16, 2016·Journal of Thrombosis and Haemostasis : JTH·R SzaboT H Bugge
Dec 3, 2016·Immunology and Cell Biology·Lazaros VasilikosWendy Wei-Lynn Wong
Sep 1, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Stefano ToldoAntonio Abbate
Oct 10, 2018·The Journal of Reproduction and Development·Toshiyuki SuzukiMasashi Takahashi
Mar 29, 2012·The Biochemical Journal·Robert C RickertCarl F Ware
Oct 3, 2015·The EMBO Journal·Maryline MoulinDavid L Vaux
Oct 3, 2015·The EMBO Journal·Kristen N HeardPhilip A Barker
Jan 25, 2014·American Journal of Respiratory and Critical Care Medicine·Tom Vanden BerghePeter Vandenabeele
Nov 6, 2012·Nature Reviews. Immunology·Peter Vandenabeele, Mathieu J M Bertrand
Aug 23, 2019·Laboratory Animals·Fernando BenavidesDirk Wedekind
May 24, 2016·Journal of Thrombosis and Haemostasis : JTH·B J M van Vlijmen, R J Westrick
Jan 12, 2019·F1000Research·Najoua Lalaoui, David Lawrence Vaux
Feb 14, 2019·BMC Genomics·C FarkasR Pincheira
Nov 21, 2018·Frontiers in Immunology·Liming MaoIvan J Fuss
Jul 19, 2018·Science Signaling·Steven M ChirieleisonDerek W Abbott
Jan 11, 2020·Cell·Fanny MatheisDaniel Mucida
Nov 1, 2020·Current Opinion in Microbiology·Stefan A FattingerWolf-Dietrich Hardt
Jan 26, 2021·IScience·Renan V H de CarvalhoDario S Zamboni
Mar 12, 2021·Frontiers in Immunology·Leidy C MerselisGeorge P Munson
Jun 5, 2021·Oncotarget·Chiara ColarussoRosalinda Sorrentino
Jan 25, 2019·Journal of Medicinal Chemistry·Hui CongChunlin Zhuang