An incoherent feed-forward loop switches the Arabidopsis clock rapidly between two hysteretic states

Scientific Reports
Ignasius JoanitoChao-Ping Hsu

Abstract

In higher plants (e.g., Arabidopsis thaliana), the core structure of the circadian clock is mostly governed by a repression process with very few direct activators. With a series of simplified models, we studied the underlying mechanism and found that the Arabidopsis clock consists of type-2 incoherent feed-forward loops (IFFLs), one of them creating a pulse-like expression in PRR9/7. The double-negative feedback loop between CCA1/LHY and PRR5/TOC1 generates a bistable, hysteretic behavior in the Arabidopsis circadian clock. We found that the IFFL involving PRR9/7 breaks the bistability and moves the system forward with a rapid pulse in the daytime, and the evening complex (EC) breaks it in the evening. With this illustration, we can intuitively explain the behavior of the clock under mutant conditions. Thus, our results provide new insights into the underlying network structures of the Arabidopsis core oscillator.

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Citations

Jun 18, 2020·Frontiers in Genetics·Lisa Van den BroeckRosangela Sozzani
Sep 4, 2020·PLoS Computational Biology·Ignasius JoanitoChao-Ping Hsu
Feb 3, 2019·Nature Communications·Alex A R WebbCamila Caldana
Dec 12, 2020·IScience·Junmin WangSamuel A Isaacson
Feb 19, 2020·Molecular Plant·Sabrina E SanchezSteve A Kay
Jul 29, 2021·PLoS Computational Biology·Saurabh ModiAbhyudai Singh

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Software Mentioned

Pos
Octave
P2012
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