An increase in intracellular [Na+] during Ca2+ depletion is not related to Ca2+ paradox damage in rat hearts

The American Journal of Physiology
M A JansenT J Ruigrok

Abstract

Ca2+ paradox damage has been suggested to be determined by Na+ entry during Ca2+ depletion and exchange of Na+ for Ca2+ during Ca2+ repletion. With the use of 23Na nuclear magnetic resonance, we previously observed a Ca2+ paradox without a prior Na+ increase. We have now demonstrated a Na+ increase during Ca2+ and Mg2+ depletion without the occurrence of the Ca2+ paradox during Ca2+ repletion. Isolated rat hearts were perfused for 20 min with a Ca(2+)-free or a Ca(2+)- and Mg(2+)-free (Ca2+/Mg(2+)-free) solution under hypothermic conditions (20 and 25 degrees C). Intracellular Na+ concentration ([Na+]i) increased from 11.9 +/- 1.2 to 26.9 +/- 5.8 mM (P < 0.001) during Ca2+/Mg(2+)-free perfusion at 20 degrees C, whereas no significant change in [Na+]i occurred during 20 min of Ca(2+)-free perfusion at 20 degrees C. In addition, we confirmed that [Na+]i did not change significantly during 20 min of normothermic Ca(2+)-free perfusion. Creatine kinase release during normothermic Ca2+ repletion in the 20 degrees C groups was approximately 10% and in the 25 degrees C groups 75% of the release in the normothermia group. Recovery of rate-pressure product was approximately 50% in the 20 degrees C groups versus 0% in the normothermia gro...Continue Reading

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Citations

Nov 13, 2004·American Journal of Physiology. Cell Physiology·Youngran ChungThomas Jue
Jan 20, 2006·American Journal of Physiology. Cell Physiology·Youngran ChungThomas Jue
Jul 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Coral L Murrant
Jan 6, 2007·Journal of Applied Physiology·Richard A HowlettMichael C Hogan

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