An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or septic shock

PloS One
Chan Ho KimHyung Jung Oh

Abstract

Mean platelet volume (MPV) is suggested as an index of inflammation, disease activity, and anti-inflammatory treatment efficacy in chronic inflammatory disorders; however, the effect of MPV on sepsis mortality remains unclear. Therefore, we investigated whether the change in MPV between hospital admission and 72 hours (ΔMPV72h-adm) predicts 28-day mortality in severe sepsis and/or septic shock. We prospectively enrolled 345 patients admitted to the emergency department (ED) who received standardized resuscitation (early goal-directed therapy) for severe sepsis and/or septic shock between November 2007 and December 2011. Changes in platelet indices, including ΔMPV72h-adm, were compared between survivors and non-survivors by linear mixed model analysis. The prognostic value of ΔMPV72h-adm for 28-day mortality was ascertained by Cox proportional hazards model analysis. Thirty-five (10.1%) patients died within 28 days after ED admission. MPV increased significantly during the first 72 hours in non-survivors (P = 0.001) and survivors (P < 0.001); however, the rate of MPV increase was significantly higher in non-survivors (P = 0.003). Nonetheless, the difference in the platelet decline rate over the first 72 hours did not differ sign...Continue Reading

References

Nov 1, 1990·The Journal of Surgical Research·T TaniguchiT Tanaka
Jun 1, 1983·Journal of Clinical Pathology·J Van der Lelie, A K Von dem Borne
Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Jun 1, 1993·Blood Reviews·S R Jackson, J M Carter
Apr 1, 1997·Intensive Care Medicine·M GawazF J Neumann
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Apr 10, 2002·Critical Care Medicine·Serdar AkcaJean Louis Vincent
May 11, 2002·Critical Care Medicine·Jean-Louis VincentOlivier Pradier
Feb 21, 2004·Stroke; a Journal of Cerebral Circulation·Philip BathUNKNOWN PROGRESS Collaborative Group
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Walter T Linde-Zwirble, Derek C Angus
Dec 23, 2004·Journal of Thrombosis and Haemostasis : JTH·A YaguchiO Pradier
Jun 6, 2007·International Journal of Colorectal Disease·Hasan KayahanHale Akpinar
Jun 22, 2007·Critical Care Medicine·Henry E WangDonald M Yealy
Dec 26, 2007·Critical Care Medicine·R Phillip DellingerUNKNOWN World Federation of Societies of Intensive and Critical Care Medicine
May 20, 2009·International Journal of Laboratory Hematology·C Briggs
Jun 6, 2009·Journal of Thrombosis and Haemostasis : JTH·S K BraekkanJ B Hansen
Nov 13, 2009·Inflammation & Allergy Drug Targets·Armen Yuri GasparyanGeorge D Kitas
Jan 21, 2011·Current Pharmaceutical Design·Armen Yuri GasparyanGeorge D Kitas
Nov 25, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Yucel Colkesen, Haldun Muderrisoglu
Mar 15, 2012·Annals of Medicine·Avi LeaderMichael Lishner
Oct 30, 2012·The American Journal of Cardiology·Binita ShahJeffrey S Berger
Nov 6, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Karolina Akinosoglou, Efstratios Apostolakis
Jul 3, 2013·Internal Medicine·Takatoshi KitazawaHiroshi Yotsuyanagi
Sep 4, 2013·Critical Care : the Official Journal of the Critical Care Forum·Olivier GarraudFabrice Cognasse
Sep 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Murali ShyamsundarAndrew P Walden
Oct 10, 2013·Thrombosis Research·Karolina Akinosoglou, Dimitrios Alexopoulos

❮ Previous
Next ❯

Citations

Jan 14, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ahmet SahbazUlku Ozmen
Mar 12, 2016·Critical Care Research and Practice·Pattraporn TajarernmuangKaweesak Chittawatanarat
Nov 19, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ibrahim Ilker OzMustafa Acıkgoz
Feb 6, 2017·The Journal of Obstetrics and Gynaecology Research·Cift TayfurOzdemir Orcun
Jun 22, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Noha BoshnakHatem Elgohary
Jan 13, 2018·The Journal of International Medical Research·Sheng YeDan Xu
Feb 22, 2018·Canadian Journal of Gastroenterology & Hepatology·Tamara Milovanovic AlempijevicTomica Milosavljevic
Jun 12, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hebatallah A Shaaban, Nesma Safwat
Oct 18, 2019·PloS One·Fanny Vardon-BounesVincent Minville
Jun 9, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Martín AnguloGastón Burghi
Aug 13, 2020·Circulation Research·Dong Heon LeeAndrew D Johnson
Dec 2, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Mauro ButtarelloMario Plebani
Jul 16, 2015·Expert Review of Hematology·Giuseppe Lippi, Massimo Franchini
Apr 22, 2020·Proceedings·Somedeb BallKenneth Nugent
Sep 27, 2018·BMC Emergency Medicine·Antonella CotoiaFabio Silvio Taccone
Sep 20, 2020·Molecular Oral Microbiology·William A ChenDanilo S Boskovic
Nov 1, 2020·Journal of Clinical Laboratory Analysis·Qingyang Zhong, Jie Peng
Oct 16, 2020·Minerva anestesiologica·Stefano Skurzak, Roberto Balagna
Mar 31, 2021·British Journal of Haematology·Janine CollinsDragana Vuckovic
Mar 30, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sridhar MangaleshAjay Malik
Oct 17, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ghada Al Harbi, Anis Chaari
May 11, 2021·COPD·Jaime A Gómez-RoseroFabián Jaimes
Jun 10, 2021·The Journal of Obstetrics and Gynaecology Research·Cenk SoysalOnur İnce
Oct 16, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Xinghui WuHuasheng Tong
Oct 15, 2021·International Journal of Immunopathology and Pharmacology·Alaa EfatAly Elkholy
Dec 16, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Pınar Erdoğan, Alirıza Erdoğan

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here