PMID: 19122345Jan 6, 2009Paper

An increase in serum retinol-binding protein 4 in the type 2 diabetic subjects with nephropathy

Endocrine Journal
Miho MurataSan-E Ishikawa

Abstract

The present study was undertaken to determine retinol-binding protein 4 (RBP4) levels in subjects with diabetic nephropathy. A total of 149 type 2 diabetic subjects and 19 control subjects were enrolled. Serum levels of RBP4 were measured by a method of ELISA. Serum RBP4 levels were significantly greater in the subjects with type 2 diabetes mellitus than the controls (70.5 +/- 35.3 vs. 40.1 +/- 13.0 microg/ml, mean +/- SD, p<0.01). Serum RBP4 levels were gradually increased according to the progression of diabetic nephropathy (p value in trend test: <0.001). Its elevation was significantly greater in the diabetic subjects with stages 1, 3B and 4 than the control subjects (Stage 1: 64.6 +/- 29.7, Stage 3B: 123.3 +/- 71.8, Stage 4: 91.4 +/- 33.8 vs. 40.1 +/- 13.0 microg/ml, p<0.01). Similar results were obtained in the subjects based on the amount of albuminuria (Normo-: 64.6 +/- 29.7, Micro-: 63.7 +/- 29.4, and Marcoalbuminuria: 90.3 +/- 44.6 microg/ml, p <0.001). Serum RBP4 levels had a positive correlation with serum creatinine levels(r = 0.377, p<0.001), and a negative correlation with 1/creatinine (r = -0.420, p<0.001). Also, there was a negative correlation between serum RBP4 and the estimated glomerular filtration rate(r =...Continue Reading

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Citations

Aug 13, 2011·European Journal of Endocrinology·Primoz KotnikMartin Wabitsch
May 4, 2010·Journal of Endocrinological Investigation·E AkbayA Kiykim
Dec 15, 2010·Diabetes Research and Clinical Practice·Wenchao Hu, Ping Feng
May 31, 2012·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·H ParkM L Shaffer
Nov 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Pedro M Moraes-VieiraBarbara B Kahn
Feb 1, 2019·Pharmacology & Therapeutics·William S Blaner

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