An increase of fractional exhaled nitric oxide after specific inhalation challenge is highly predictive of occupational asthma

International Archives of Occupational and Environmental Health
Julia EngelR Merget

Abstract

An increase of fractional exhaled nitric oxide (FeNO) has been described after specific inhalation challenges (SICs) with occupational allergens, but the clinical role of FeNO measurements before and after SIC is unknown. It was the aim of this study to assess the diagnostic accuracy of FeNO measurements before and after SIC in subjects with suspected occupational asthma (OA). One hundred forty-eight patients with suspected OA were examined by SIC with various occupational allergens. Subjects were assigned to pulmonary responders, nonresponders or doubtful by standard lung function criteria. FeNO was measured before SIC (baseline) and 24 h afterwards. Subjects with negative or doubtful SIC but increase of FeNO were evaluated individually by an overall expert rating. Effect modifiers of FeNO increases were assessed by regression analyses. Thirty-one patients (21%) were classified as pulmonary responders, 105 (71%) as nonresponders and 12 (8%) as doubtful. With the pulmonary responder status as gold standard an increase of FeNO ≥ 13 ppb showed a specificity of 0.9 and a sensitivity of 0.5. Seventeen subjects with negative or doubtful responder status showed such an increase of FeNO, among them 13 subjects with definitive or proba...Continue Reading

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Citations

Oct 16, 2018·Current Opinion in Pulmonary Medicine·Santiago Quirce, Joaquín Sastre
Oct 28, 2019·Current Opinion in Allergy and Clinical Immunology·Ida MogensenAndrei Malinovschi
Jun 7, 2019·American Journal of Industrial Medicine·Vera van KampenRolf Merget
Dec 19, 2019·Current Opinion in Allergy and Clinical Immunology·Mohamed F Jeebhay, Roslynn Baatjies
May 31, 2019·International Archives of Occupational and Environmental Health·Julia EngelRolf Merget
Jul 1, 2020·International Journal of Environmental Research and Public Health·Angelica I TiotiuDenislava Nedeva
Jan 21, 2019·Allergy, Asthma & Immunology Research·Ambrose Lau, Susan M Tarlo
Nov 27, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Diana BetancorJoaquin Sastre
Aug 3, 2021·Frontiers in Genetics·Laura W TaylorLeena A Nylander-French

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