PMID: 7543611Sep 1, 1995Paper

An increase of neuropeptide Y but not nitric oxide synthase-immunoreactive nerves in the bladder neck from male patients with bladder neck dyssynergia

The Journal of Urology
R CroweG Burnstock

Abstract

To determine the distribution of neuropeptides in male patients with bladder neck dyssynergia and benign prostatic hyperplasia. Bladder neck tissue, obtained from male patients with bladder neck dyssynergia (BND) and control patients with benign prostatic hyperplasia (BPH), was studied immunohistochemically for protein gene product 9.5 (a general neuronal marker), vasoactive intestinal polypeptide, neuropeptide Y, calcitonin gene-related peptide, substance P, growth associated protein 43 and nitric oxide synthase. In the bladder neck from control patients, the greatest density of nerves contained protein gene product 9.5, followed in decreasing order by neuropeptide Y; vasoactive intestinal polypeptide; calcitonin gene-related peptide; nitric oxide synthase; substance P and serotonin. The neuropeptides were found in the smooth muscle and were also associated with blood vessels. In patients with BND there was a statistically significant increase (P < 0.05) in the density of protein gene product 9.5- and neuropeptide Y-immunoreactive nerves in the smooth muscle and the base of the mucosa but not in blood vessels in the bladder neck, while the density of the other neuropeptides studied, nitric oxide synthase and serotonin did not ...Continue Reading

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Citations

Jun 28, 2005·Current Urology Reports·Chad Huckabay, Victor W Nitti
Feb 19, 2005·Current Urology Reports·Neil H GrafsteinKenneth I Glassberg
Sep 21, 2007·Current Urology Reports·Priya Padmanabhan, Victor W Nitti
Dec 21, 2002·Urology·Roger R Dmochowski, David Staskin
Dec 11, 2013·Nature Reviews. Urology·Nadir I Osman, Christopher R Chapple
Jul 26, 2014·Current Urology Reports·Ashley B King, Howard B Goldman
Jul 20, 2002·The Journal of Urology·Stephen Shei Dei YangYung Tai Chen
Oct 1, 1996·The Journal of Urology·B A TrockmanG E Leach
Feb 24, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Neville Ngai-Chung TamShuk-Mei Ho
Apr 21, 2016·Expert Opinion on Drug Metabolism & Toxicology·Joshua A CohnRoger R Dmochowski
May 3, 2000·BJU International·B DavisM C Michel
Jan 1, 1997·The Journal of Urology·C Van de BeekR A Janknegt
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein
Jun 9, 2020·Lower Urinary Tract Symptoms·Hueih Ling OngHann-Chorng Kuo

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