Abstract
To determine the distribution of neuropeptides in male patients with bladder neck dyssynergia and benign prostatic hyperplasia. Bladder neck tissue, obtained from male patients with bladder neck dyssynergia (BND) and control patients with benign prostatic hyperplasia (BPH), was studied immunohistochemically for protein gene product 9.5 (a general neuronal marker), vasoactive intestinal polypeptide, neuropeptide Y, calcitonin gene-related peptide, substance P, growth associated protein 43 and nitric oxide synthase. In the bladder neck from control patients, the greatest density of nerves contained protein gene product 9.5, followed in decreasing order by neuropeptide Y; vasoactive intestinal polypeptide; calcitonin gene-related peptide; nitric oxide synthase; substance P and serotonin. The neuropeptides were found in the smooth muscle and were also associated with blood vessels. In patients with BND there was a statistically significant increase (P < 0.05) in the density of protein gene product 9.5- and neuropeptide Y-immunoreactive nerves in the smooth muscle and the base of the mucosa but not in blood vessels in the bladder neck, while the density of the other neuropeptides studied, nitric oxide synthase and serotonin did not ...Continue Reading
References
Aug 1, 1979·Experimental Neurology·P T Purinton, J E Oliver
Jan 1, 1977·Urologia Internationalis·J A Gosling, S A Thompson
Dec 19, 1975·Brain Research·T HökfeltB Pernow
Aug 31, 1992·Neuroscience Letters·A BelaiG Burnstock
Jan 9, 1992·The New England Journal of Medicine·J RajferL J Ignarro
May 1, 1992·Scientific American·S H Snyder, D S Bredt
Jun 1, 1992·British Journal of Pharmacology·K Persson, K E Andersson
Jan 1, 1992·The Journal of Physiology·K D ThornburyN G McHale
Jul 1, 1991·British Journal of Urology·R CroweG Burnstock
Aug 1, 1987·British Journal of Urology·P KlarskovT Hald
Jan 5, 1985·Lancet·R CroweG Burnstock
Oct 1, 1987·British Journal of Urology·P Klarskov
Jan 1, 1987·British Journal of Urology·P Klarskov
Jan 1, 1974·Urologia Internationalis·K Stockamp, F Schreiter
Jan 1, 1972·Scandinavian Journal of Urology and Nephrology·A Nergårdh, L O Boréus
Apr 6, 1984·European Journal of Pharmacology·J HillsG Burnstock
Oct 1, 1984·Urology·J GuJ M Polak
Jun 1, 1983·Urology·D Mitolo-ChieppaM R Carratú
Jul 1, 1983·Journal of the Autonomic Nervous System·F Magni, C Carobi
Jul 1, 1955·The Journal of Experimental Medicine·A H COONSJ M CONNOLLY
Citations
Dec 25, 2004·Urological Research·Erdal Yilmaz, Nihat Arikan
Jun 28, 2005·Current Urology Reports·Chad Huckabay, Victor W Nitti
Feb 19, 2005·Current Urology Reports·Neil H GrafsteinKenneth I Glassberg
Sep 21, 2007·Current Urology Reports·Priya Padmanabhan, Victor W Nitti
Dec 21, 2002·Urology·Roger R Dmochowski, David Staskin
Jun 1, 1996·Urology·S A KaplanM I Miller
Apr 2, 2003·European Urology·Chung Cheng WangJui Hsiang Hsieh
Feb 23, 2000·Neuroscience·C T ChienC F Chen
Oct 15, 2013·Journal of Molecular Neuroscience : MN·Zenon Pidsudko
Dec 11, 2013·Nature Reviews. Urology·Nadir I Osman, Christopher R Chapple
Jul 26, 2014·Current Urology Reports·Ashley B King, Howard B Goldman
Oct 24, 2007·European Urology·Sey Kiat Lim, Pearllyn L C Quek
Jul 20, 2002·The Journal of Urology·Stephen Shei Dei YangYung Tai Chen
Jul 20, 1999·The Journal of Urology·F H MumtazR J Morgan
Oct 1, 1996·The Journal of Urology·B A TrockmanG E Leach
Feb 24, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Neville Ngai-Chung TamShuk-Mei Ho
Apr 21, 2016·Expert Opinion on Drug Metabolism & Toxicology·Joshua A CohnRoger R Dmochowski
Jul 5, 2011·Polish Journal of Veterinary Sciences·E LepiarczykM Majewski
May 3, 2000·BJU International·B DavisM C Michel
Jun 7, 2002·The Journal of Urology·Victor W NittiChristopher M Dixon
Jan 1, 1997·The Journal of Urology·C Van de BeekR A Janknegt
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein
Jun 9, 2020·Lower Urinary Tract Symptoms·Hueih Ling OngHann-Chorng Kuo