PMID: 9166314May 1, 1997Paper

An increase of the plasma N-terminal peptide of proatrial natriuretic peptide in preeclampsia

Obstetrics and Gynecology
A M PoutaT J Laatikainen

Abstract

To determine whether increased concentrations of the N-terminal peptide of proatrial natriuretic peptide and of atrial natriuretic peptide are related to the severity of preeclampsia and gestational hypertension. Blood samples were collected from 70 healthy pregnant women, 48 women with preeclampsia, and 19 women with gestational hypertension in the third trimester. We used a specific radioimmunoassay (RIA) method suitable for the determination of the plasma N-terminal peptide of proatrial natriuretic peptide in unextracted plasma. The atrial natriuretic peptide was measured by RIA from Sep-Pak C18-extracted plasma. The N-terminal peptide of proatrial natriuretic peptide levels were significantly higher in preeclamptic women than in healthy pregnant controls (median 571 [range 189-2000] versus 266 pmol/L [80-634], P < .001) and also significantly higher in women with severe preeclampsia than in women with mild preeclampsia (766 [431-2000] versus 492 pmol/L [189-1283], P = .01). The N-terminal peptide of proatrial natriuretic peptide values were significantly elevated in the subgroup of hypertensive pregnancies with abnormal Doppler velocimetry. At entry into the study the values for the N-terminal peptide of proatrial natriuret...Continue Reading

References

May 11, 1991·American Journal of Obstetrics and Gynecology·R W MerkourisD L Vesely
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·R N TaylorJ M Roberts
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Citations

Jul 11, 2013·Stem Cells International·Chuck C-K ChaoJack J Chao
Jul 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·W YanQ Wu
Jan 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Joyce C Y ChanQingyu Wu
Jun 11, 2011·Pathology Research International·André BarkhordarianFrancesco Chiappelli
Nov 3, 2012·International Journal of Biomaterials·Marta MonjoJan Eirik Ellingsen
Oct 10, 2014·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A KhalilK H Nicolaides
Apr 4, 2007·American Journal of Obstetrics and Gynecology·Kati M TihtonenJukka T Uotila
Jun 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Katherine L TranQingyu Wu
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia

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