PMID: 7470763Jan 1, 1980Paper

An increased calcium sensitivity of mesenteric resistance vessels in young and adult spontaneously hypertensive rats

British Journal of Pharmacology
M J Mulvany, N Nyborg

Abstract

1. We have measured the calcium sensitivity in response to noradrenaline stimulation and potassium depolarization of isolated segments of 100 to 200 micrometer mesenteric resistance vessels from spontaneously hypertensive (SHR) and control Wistar-Kyoto rats. The rats were either young (4 wk) or adult (4 months), that is of ages before or after the SHRs had developed elevated blood pressure. Experiments were performed under conditions in which the effect of noradrenaline uptake by, and the potassium-induced noradrenaline release from, the nerve terminals in the vessel walls was eliminated. 2. The response of the SHR and WKY vessels to noradrenaline under conditions where only the extracellular calcium appeared to have been removed was similar. When subsequently stimulated maximally by noradrenaline, the calcium-sensitivity of the SHR vessels (Ca-ED50 approximately or equal to 0.1 mM) was greater than that of the WKY vessels (Ca-ED50 approximately or equal to 0.2 mM). When depolarized by potassium, all vessels were less sensitive to calcium and there was little difference in the calcium sensitivity of SHR and WKY vessels in either age group (Ca-ED50 approximately or equal to 0.8 mM). 3. The results suggest that whereas the potass...Continue Reading

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Citations

Apr 1, 1994·Pflügers Archiv : European journal of physiology·P J BoelsB Uvelius
Dec 1, 1987·Pflügers Archiv : European journal of physiology·N C NyborgM J Mulvany
Jan 1, 1989·International Ophthalmology·P J Nielsen, N C Nyborg
Mar 1, 1990·Cardiovascular Drugs and Therapy·J D Swales
Jun 1, 2010·Heart and Vessels·Maria Esther Rubio-RuizVerónica Guarner-Lans
Oct 14, 2004·Pflügers Archiv : European journal of physiology·Olaf GriskRainer Rettig
Jan 23, 1987·The American Journal of Cardiology·L P ThompsonR C Webb
Nov 3, 1987·European Journal of Pharmacology·T D White, J A Angus
Mar 3, 1987·European Journal of Pharmacology·B JuulM J Mulvany
Sep 21, 1990·European Journal of Pharmacology·N C Nyborg, E O Mikkelsen
Jun 6, 1991·European Journal of Pharmacology·M MessingH A Struyker-Boudier
Feb 1, 1994·Mathematical Biosciences·J M Gonzalez-Fernandez, B Ermentrout
Jan 1, 1983·Pharmacology & Therapeutics·S Lipe, R F Moulds
May 1, 1994·Journal of the Autonomic Nervous System·D PrietoA García-Sacristán
Jan 20, 2004·European Journal of Pharmacology·Majid Sheykhzade, Niels C Berg Nyborg
Feb 8, 2003·Regulatory Peptides·Tórur DalsgaardBent Ottesen
May 8, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rudolph SchutteLeoné Malan
May 12, 2000·British Journal of Pharmacology·M Sheykhzade, N C Nyborg
Mar 17, 2001·British Journal of Pharmacology·M Sheykhzade, N C Berg Nyborg
Jul 22, 1982·The New England Journal of Medicine·D A McCarron
Jan 5, 2013·Journal of Cardiovascular Pharmacology·Bunyen TengS Jamal Mustafa
Feb 1, 1987·Clinical and Experimental Pharmacology & Physiology·C A HamiltonJ L Reid
Aug 1, 1990·Clinical and Experimental Pharmacology & Physiology·M T HallI W Rodger
Jan 1, 1991·Clinical and Experimental Pharmacology & Physiology·M J Mulvany
Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology. Supplement·K R LeesJ L Reid
Apr 1, 1996·Journal of Gastroenterology and Hepatology·C S LayS Chien
Apr 1, 1993·British Journal of Pharmacology·S LeiM J Mulvany
Apr 1, 1993·British Journal of Pharmacology·P ArvolaI Pörsti
Aug 1, 1993·British Journal of Pharmacology·U SimonsenA García-Sacristán

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