PMID: 9161699Jan 1, 1996Paper

An increased incidence of thyroid antibodies in patients with Turner's syndrome and their first degree relatives

Autoimmunity
R WilsonJ M Connor

Abstract

Previous studies have suggested that there may be a link between Turner's syndrome and autoimmunity. The numbers involved in these studies have tended to be small and few studies have included family members. This study has compared the incidence of thyroid antibodies in the serum of 60 patients with Turner' syndrome and 50 of their mothers with 127 controls. Total T4 and TSH levels were also measured. Of the 60 patients with Turner's syndrome 18 (30%) were positive for either thyroid peroxidase (TPO) and/or thyroglobulin antibodies. The peak incidence of thyroid antibodies occurred at 13 years of age. 11 (22%) of the mothers were also antibody positive. The incidence of thyroid antibodies was significantly higher in both the patients with Turner's Syndrome (30 vs 1.7% p < 0.001) and their mothers (22 vs 6.6% p < 0.05) than in the control groups. The increased incidence of thyroid antibodies found in these patients and their mothers confirms that there is an association between Turner's Syndrome and autoimmunity. However unlike previous studies we found more patients were positive for thyroglobulin than TPO antibodies.

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Citations

Sep 29, 2005·Thyroid : Official Journal of the American Thyroid Association·S LivadasC Dacou-Voutetakis
Apr 25, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·C C MedeirosA T Maciel-Guerra
Sep 15, 2009·Clinical and Experimental Dermatology·S I Goolamali, S M Neill
Feb 27, 2013·Pediatric Dermatology·Maria LagerstedtSatu-Leena Laasanen
Jul 29, 2006·Journal of Pediatric and Adolescent Gynecology·Shahryar K KavoussiYolanda R Smith
Jan 6, 2012·Arquivos brasileiros de endocrinologia e metabologia·Paulo Ferrez Collett-SolbergMarilia Martins Guimarães
Sep 18, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Rui-Min ChenXin Yuan
Mar 1, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Rasha T HamzaKhaled O Abdallah
Jun 5, 2007·Arquivos brasileiros de endocrinologia e metabologia·Carla C M MedeirosAndréa T Maciel-Guerra

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