PMID: 1451957Oct 1, 1992

An increased level of antibodies to beta-lactoglobulin is a risk determinant for early-onset type 1 (insulin-dependent) diabetes mellitus independent of islet cell antibodies and early introduction of cow's milk

G DahlquistM Landin-Olsson


Using a case-control design we have studied whether antibodies to cow's milk proteins are risk determinants for childhood-onset Type 1 (insulin-dependent) diabetes mellitus independent of early exposure to cow's milk formula and islet cell antibodies. Sera from 116 recent-onset diabetic children and 112 age- and sex-matched control children were analysed for cow's milk protein IgA, IgG and IgM antibodies, beta-lactoglobulin IgA and IgM antibodies and islet cell antibodies. The titres were compared to questionnaire data on duration of breast-feeding and introduction of formula feeding. Most antibody levels tended to be increased among diabetic compared to control children. This was statistically significant for cow's milk protein IgA antibodies (p less than 0.001) and beta-lactoglobulin IgA antibodies (p less than 0.01) as well as for islet cell antibody-positivity which was found among 92% of the diabetic and 3% of control children. The differences in cow's milk protein antibodies as well as beta-lactoglobulin antibodies were more pronounced among children with an early onset of Type 1 diabetes. Breast-feeding duration was significantly inversely related to the log of beta-lactoglobulin IgG (r = -0.16, p = 0.04) and the log of ...Continue Reading


Jan 1, 1995·Molecular Aspects of Medicine·W J KargesH M Dosch
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Deryck R Persaud, Alma Barranco-Mendoza
Jan 17, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hans K AkerblomJorma Ilonen
Feb 28, 2001·Journal of Immunological Methods·Annette PlesnerA Lernmark
Apr 9, 2008·The British Journal of Nutrition·Claudio Maffeis, Leonardo Pinelli
Apr 12, 2000·Journal of the American College of Nutrition·J Schrezenmeir, A Jagla
Dec 1, 1994·Scandinavian Journal of Immunology·R CheungH M Dosch
Jun 1, 1994·Postgraduate Medical Journal·R Taylor, M Vanderpump
Sep 4, 1999·Journal of Endocrinological Investigation·J Norris, M Pietropaolo
Jul 1, 1996·Diabetes Research and Clinical Practice·J E TookeA C Shore
Dec 4, 2003·Biochemical and Biophysical Research Communications·Javier AnguloIñigo Sáenz de Tejada
Dec 1, 1994·Acta Physiologica Scandinavica·T Jun, A Wennmalm
Apr 1, 1994·Journal of Internal Medicine·A Wennmalm
Apr 22, 2014·FEBS Letters·Dennis S NielsenAxel K Hansen
Dec 1, 1994·Annals of Medicine·Suvi M Virtanen, A Aro
Jul 13, 2002·American Journal of Medical Genetics·Hans K AkerblomMikael Knip
Mar 10, 2001·Pediatric Clinics of North America·M K Davis
Apr 7, 2005·Nutrition·Sandra SipetićSilvija Sajic
Oct 5, 1996·Lancet·L C Harrison
Dec 28, 1999·Journal of the American Dietetic Association·P Z MarincicD G Hendricks
Nov 7, 1999·Journal of Autoimmunity·E SarugeriE Bonifacio
Nov 25, 2005·Diabetes·Mikael KnipHans K Akerblom
Mar 26, 2010·The American Journal of Clinical Nutrition·Mikael KnipHans K Akerblom
Jan 21, 2011·Physiological Reviews·Tom L van BelleMatthias G von Herrath
Jan 16, 2020·World Journal of Diabetes·Adebola Matthew GiwaAbdel Rahim A Hamad
Sep 4, 1999·Journal of Endocrinological Investigation·P Pozzilli
Jul 1, 1994·Journal of Endocrinological Investigation·J Norris, M Pietropaolo
Dec 12, 2003·The American Journal of Clinical Nutrition·Suvi M Virtanen, Mikael Knip
Jul 1, 1994·Journal of Endocrinological Investigation·E Bosi, E Bonifacio
Jan 11, 2000·The Proceedings of the Nutrition Society·H E Wasmuth, H Kolb
Mar 17, 2020·Frontiers in Endocrinology·Sandra DedrickEmrah Altindis
Apr 10, 2020·Diabetes/metabolism Research and Reviews·Adar AdiRachmiel Marianna
May 23, 2002·Annals of the New York Academy of Sciences·P E R Brandtzaeg


Mar 1, 1990·The American Journal of Clinical Nutrition·Fraser W Scott
May 19, 1990·BMJ : British Medical Journal·G DahlquistS G Wall
Jan 1, 1985·International Archives of Allergy and Applied Immunology·Q HuangD R Stanworth
Nov 25, 1972·Lancet·R B Tattersall, D A Pyke
Jan 1, 1971·International Archives of Allergy and Applied Immunology·B KletterA M Davies
Apr 1, 1984·Diabetologia·R B Elliott, J M Martin

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