An Individual Interneuron Participates in Many Kinds of Inhibition and Innervates Much of the Mouse Visual Thalamus.

Neuron
Josh Lyskowski Morgan, Jeff William Lichtman

Abstract

One way to assess a neuron's function is to describe all its inputs and outputs. With this goal in mind, we used serial section electron microscopy to map 899 synaptic inputs and 623 outputs in one inhibitory interneuron in a large volume of the mouse visual thalamus. This neuron innervated 256 thalamocortical cells spread across functionally distinct subregions of the visual thalamus. All but one of its neurites were bifunctional, innervating thalamocortical and local interneurons while also receiving synapses from the retina. We observed a wide variety of local synaptic motifs. While this neuron innervated many cells weakly, with single en passant synapses, it also deployed specialized branches that climbed along other dendrites to form strong multi-synaptic connections with a subset of partners. This neuron's diverse range of synaptic relationships allows it to participate in a mix of global and local processing but defies assigning it a single circuit function.

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Citations

Apr 4, 2020·Nature Reviews. Neuroscience·Natasha Bray
Sep 4, 2020·ELife·Louis K SchefferStephen M Plaza
Feb 25, 2021·Scientific Reports·Giuseppe GiacopelliMichele Migliore
Feb 26, 2021·Nature·Christopher A BrittinNetta Cohen
Mar 27, 2021·Neuroscience and Biobehavioral Reviews·Christian O'ReillySean L Hill
May 22, 2020·Cell Systems·Rune Rasmussen, Ubadah Sabbagh
Jun 9, 2021·Neural Regeneration Research·Charles L Zucker, John E Dowling
Jun 24, 2021·Scientific Reports·Jordan K MatelskyWilliam Gray-Roncal

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