An indomethacin-sensitive contraction induced by beta-antagonists in guinea pig airways

Canadian Journal of Physiology and Pharmacology
Fredrik JohanssonSamuel S Svensson

Abstract

Beta-adrenergic receptor (beta-AR) antagonists have been associated with increased airway reactivity in asthmatics and potentiation of contractile stimuli in animal models. In the present study, using an in vitro model of tracheal preparations from guinea pigs, we show that the beta-AR antagonists propranolol and pindolol induce a smooth muscle contraction. A prerequisite for this contraction is that the airway preparations have been pre-treated with an beta-AR agonist. Our data show that the contractile effect of beta-AR antagonists is not a simple consequence of reversing the agonist-induced relaxation. Furthermore, the effect seems to be mediated through interaction with beta2-ARs since the response is stereo-selective, and the selective beta1-AR receptor antagonist atenolol did not induce any contractile response. SQ 29,546, a thromboxane A2 antagonist; MK 886, a lipoxygenase inhibitor; and indomethacin, a cyclooxygenase inhibitor significantly inhibited the contractions of the tracheal preparations induced with propranolol or pindolol. We put forward the hypothesis that the contractile effect of the beta-AR antagonist is a consequence of their inverse agonist activity, which is only evident when the receptor population hav...Continue Reading

References

Jul 1, 1979·British Journal of Pharmacology·J Maclagan, U M Ney
May 1, 1992·Journal of Applied Physiology·N GrundströmR G Andersson
Aug 1, 1983·British Journal of Pharmacology·U M Ney
Aug 1, 1981·Acta Pharmacologica Et Toxicologica·N GrundströmJ E Wikberg
Mar 1, 1995·Journal of Lipid Mediators and Cell Signalling·N SongürT Matsuda
Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·N SongürT Matsuda
Jan 29, 1993·Cell·L L LinR J Davis
Nov 5, 1997·Advances in Pharmacology·R J LefkowitzY Daaka
May 23, 1998·Annual Review of Pharmacology and Toxicology·J G Krupnick, J L Benovic
Apr 20, 1999·Pulmonary Pharmacology & Therapeutics·E A SeedsC P Page
Jun 22, 2001·European Journal of Clinical Pharmacology·A VatrellaS A Marsico

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.