An induced blood pressure rise does not alter upper airway resistance in sleeping humans

Journal of Applied Physiology
C R WilsonJ A Dempsey

Abstract

Sleep apnea is associated with episodic increases in systemic blood pressure. We investigated whether transient increases in arterial pressure altered upper airway resistance and/or breathing pattern in nine sleeping humans (snorers and nonsnorers). A pressure-tipped catheter was placed below the base of the tongue, and flow was measured from a nose or face mask. During non-rapid-eye-movement sleep, we injected 40- to 200-microgram i.v. boluses of phenylephrine. Parasympathetic blockade was used if bradycardia was excessive. Mean arterial pressure (MAP) rose by 20 +/- 5 (mean +/- SD) mmHg (range 12-37 mmHg) within 12 s and remained elevated for 105 s. There were no significant changes in inspiratory or expiratory pharyngeal resistance (measured at peak flow, peak pressure, 0.2 l/s or by evaluating the dynamic pressure-flow relationship). At peak MAP, end-tidal CO2 pressure fell by 1.5 Torr and remained low for 20-25 s. At 26 s after peak MAP, tidal volume fell by 19%, consistent with hypocapnic ventilatory inhibition. We conclude that transient increases in MAP of a magnitude commonly observed during non-rapid-eye-movement sleep-disordered breathing do not increase upper airway resistance and, therefore, will not perpetuate sub...Continue Reading

References

Sep 1, 1975·Journal of Applied Physiology·M M GrunsteinJ Milic-Emili
Nov 1, 1992·Journal of Applied Physiology·E GarpestadJ W Weiss
Jan 1, 1992·Journal of Applied Physiology·E GarpestadJ W Weiss
Feb 1, 1992·Journal of Applied Physiology·R Stoohs, C Guilleminault
Dec 1, 1990·Journal of Cardiovascular Pharmacology·J MayerJ H Peter
Nov 11, 1991·The American Review of Respiratory Disease·M J WasickoD Bartlett
Nov 1, 1988·Journal of Applied Physiology·W B Van de Graaff
Feb 1, 1988·Respiration Physiology·L G Olson, K P Strohl
Jun 1, 1987·Journal of Applied Physiology·G WarnerJ A Dempsey
Oct 1, 1986·Journal of Applied Physiology·E OnalM Lopata
Jul 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J A SalamoneN S Cherniack
Sep 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J B Skatrud, J A Dempsey
Nov 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P W JonesK Wasserman
Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·E GarpestadJ W Weiss
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·K ReesP M Calverley
Mar 1, 1994·Journal of Applied Physiology·E H Vidruk, R Sorkness
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·M R BonsignoreD Pieri
Sep 1, 1993·Journal of Applied Physiology·M J WasickoJ C Leiter
Feb 4, 1993·The New England Journal of Medicine·V K SomersF M Abboud
Feb 1, 1996·Respiration Physiology·M S Badr, A Kawak
Mar 1, 1996·Journal of Applied Physiology·C P O'DonnellJ L Robotham
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·C P O'DonnellM Shirahata
Mar 1, 1997·Journal of Applied Physiology·C A SmithJ A Dempsey
Feb 14, 1998·Journal of Applied Physiology·S KatragaddaB J Morgan

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Citations

Mar 29, 2001·Drugs·R R GrunsteinL Grote
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·A William SheelJerome A Dempsey
Sep 10, 2014·Current Opinion in Pulmonary Medicine·Manisha Jhamb, Mark Unruh
Dec 2, 2000·The Journal of Physiology·C M St CroixJ A Dempsey
Jan 21, 2010·Physiological Reviews·Jerome A DempseyChristopher P O'Donnell
Nov 6, 2007·The Journal of Experimental Biology·Michael S HedrickPhilip C Withers

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