PMID: 11321379Apr 26, 2001Paper

An infant formula free of glycomacropeptide prevents hyperthreoninemia in formula-fed preterm infants

Journal of Pediatric Gastroenterology and Nutrition
J RigoF Studzinski

Abstract

Hyperthreoninemia is a well-known phenomenon in infants fed a whey protein-predominant formula. Sweet whey is commonly used for the production of these whey-predominant infant milk formulas. Sweet whey contains not only whey proteins but also the threonine-rich glycomacropeptide (GMP). In the current study, an experimental formula based on acid whey without GMP and a formula based on sweet whey with GMP (threonine content 17.2% higher than in the experimental formula) but otherwise with identical composition were tested with particular respect to threonine metabolism. Fourteen preterm infants appropriate for gestational age were enrolled in this randomized cross-over study. After a feeding period of at least 7 days, the nutrition of each infant was switched to the other formula for the second feeding period. At the end of each feeding period, the concentrations of creatinine and amino acids in the plasma and in the urine were measured. In the plasma, the threonine concentration was significantly lower in the group fed the experimental GMP-free formula than in the group fed the sweet whey formula (P < 0.001). Renal excretion of all essential amino acids was generally very low and less than 2% of the intake, indicating that the k...Continue Reading

References

Jan 1, 1987·Biology of the Neonate·J Rigo, J Senterre
Jan 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·J Rigo, J Senterre
Aug 1, 1982·The Journal of Pediatrics·T TikanojaN C Räihä
Jul 1, 1994·The Journal of Nutrition·T A DavisP J Reeds
Sep 1, 1995·Brain & Development·M V Johnston
Jan 1, 1996·Journal of Neural Transmission·W RetzP Riederer
Jan 30, 1999·The American Journal of Clinical Nutrition·P B DarlingP B Pencharz

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Citations

Mar 10, 2007·Journal of Inherited Metabolic Disease·M GiovanniniE Riva
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·Pavan KumarDong Kee Jeong
May 10, 2005·The British Journal of Nutrition·Gigi Veereman-Wauters
Dec 24, 2005·The Journal of International Medical Research·E RivaM Giovannini
Jun 29, 2001·Journal of Pediatric Gastroenterology and Nutrition·J C PicaudB L Salle
Dec 31, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C AgostoniE Riva
Oct 11, 2005·Acta Paediatrica. Supplement·Francesco SavinoLeandra Silvestro
Apr 8, 2016·Critical Reviews in Food Science and Nutrition·Sanket G BoradAshish K Singh
Apr 11, 2008·The American Journal of Clinical Nutrition·Olof SandströmOlle Hernell
Nov 8, 2012·European Journal of Pediatrics·Nicky NieleRuurd M van Elburg
Jun 15, 2021·Frontiers in Molecular Biosciences·Nina SillnerPhilippe Schmitt-Kopplin
Jan 29, 2005·Journal of Agricultural and Food Chemistry·Takuo NakanoLech Ozimek

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