An infant with precursor natural killer (NK) cell leukemia successfully treated with an unrelated cord blood transplantation

Leukemia & Lymphoma
A SuminoeT Hara

Abstract

Here we report a case with precursor natural killer (NK) cell leukemia successfully treated with an unrelated cord blood transplantation. A 7-month-old Japanese boy was diagnosed to have NK cell leukemia based on the existence of abnormal cells in the bone marrow with the phenotype of CD3(-) /CD4(+) /CD7(-) /CD8(-) /CD16(-) /CD33(+) /CD34(-) /CD56(+) /HLA-DR(+) /NKB1(+) / CD94(+). The leukemic cells showed few azurophilic granules in the cytoplasm and weak cytotoxic activity. Although he presented with a huge mass occupying the bilateral paranasal sinuses and hepatosplenomegaly, he achieved complete remission by the conventional chemotherapeutic regimen for acute myelogenous leukemia, followed by an unrelated cord blood transplantation. He has remained in complete remission for 14 months posttransplant. To our knowledge, this is the youngest reported case with precursor NK cell leukemia; cord blood transplantation may thus be the treatment of choice for this disease.

Citations

Nov 7, 2007·Journal of Pediatric Hematology/oncology·Ann Veronique C EguarasMa Luz U Del Rosario
Aug 2, 2003·Clinical and Laboratory Haematology·J KurodaT Maekawa
Jan 10, 2006·Bone Marrow Transplantation·R SuzukiUNKNOWN NK-cell Tumor Study Group
Feb 26, 2020·Journal of Pediatric Hematology/oncology·Karine TurcotteKai Fu

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