An inflammatory cytokine signature predicts COVID-19 severity and survival.

Nature Medicine
Diane Marie Del ValleSacha Gnjatic

Abstract

Several studies have revealed that the hyper-inflammatory response induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease severity and death. However, predictive biomarkers of pathogenic inflammation to help guide targetable immune pathways are critically lacking. We implemented a rapid multiplex cytokine assay to measure serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α and IL-1β in hospitalized patients with coronavirus disease 2019 (COVID-19) upon admission to the Mount Sinai Health System in New York. Patients (n = 1,484) were followed up to 41 d after admission (median, 8 d), and clinical information, laboratory test results and patient outcomes were collected. We found that high serum IL-6, IL-8 and TNF-α levels at the time of hospitalization were strong and independent predictors of patient survival (P < 0.0001, P = 0.0205 and P = 0.0140, respectively). Notably, when adjusting for disease severity, common laboratory inflammation markers, hypoxia and other vitals, demographics, and a range of comorbidities, IL-6 and TNF-α serum levels remained independent and significant predictors of disease severity and death. These findings were validated in a second cohort of pa...Continue Reading

References

Oct 1, 1989·The Journal of Clinical Investigation·M BaggioliniS L Kunkel
Aug 12, 2004·British Journal of Cancer·J M SatagopanA D Auerbach
Aug 21, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jason T RichEric W Wang
Aug 2, 2012·Nature Reviews. Drug Discovery·Charles A DinarelloJos W M van der Meer
Mar 19, 2013·BMC Medical Research Methodology·Patrick Royston, Douglas G Altman
Feb 21, 2014·Science Translational Medicine·Marco L DavilaRenier Brentjens
Aug 31, 2016·Annual Review of Medicine·Anthony R FehrStanley Perlman
Nov 13, 2018·Biostatistics·Moritz BergerJan Beyersmann
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Apr 19, 2020·Science·John B Moore, Carl H June
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
Apr 25, 2020·Nature Reviews. Immunology·Nicolas VabretUNKNOWN Faculty
May 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiaoling XuHaiming Wei
May 8, 2020·Nature Reviews. Immunology·Miriam Merad, Jerome C Martin
May 20, 2020·The Journal of Allergy and Clinical Immunology·Tobias HeroldTobias Weinberger
May 21, 2020·Nature·Xiaonan ZhangHongzhou Lu
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Ishan ParanjpeGirish N Nadkarni
Jun 20, 2020·Clinical Lymphoma, Myeloma & Leukemia·Shashidhar S JatianiSamir Parekh
Jul 18, 2020·The New England Journal of Medicine·UNKNOWN RECOVERY Collaborative GroupMartin J Landray

❮ Previous
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Citations

Sep 24, 2020·Respiratory Research·H BurkeUNKNOWN REACT COVID investigators
Sep 17, 2020·Journal of Translational Medicine·Donogh MaguireDonald C McMillan
Jul 28, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Melania Maria AmorimLeila Katz
Oct 21, 2020·JAMA Internal Medicine·Olivier HermineUNKNOWN CORIMUNO-19 Collaborative Group
Oct 23, 2020·F1000Research·John L CanigliaKiran K Velpula
Oct 29, 2020·International Reviews of Immunology·Ashutosh KumarKamla Kant
Oct 31, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ihsane BenlyamaniGuillaume Monneret
Nov 10, 2020·Expert Opinion on Biological Therapy·Sajad KhialiTaher Entezari-Maleki
Dec 2, 2020·Respiratory Research·Jaya PonnampalamDilen Parmar
Nov 28, 2020·Critical Care : the Official Journal of the Critical Care Forum·Alberto García-SalidoUNKNOWN Spanish Pediatric Intensive Care Society working group on SARS-CoV-2 infection
Dec 3, 2020·The New England Journal of Medicine·David C Fajgenbaum, Carl H June
Dec 11, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Arnold R Eiser
Nov 20, 2020·Lab on a Chip·Yujing SongKatsuo Kurabayashi
Jan 5, 2021·Cytometry. Part B, Clinical Cytometry·Suraj Saksena, Pratip Chattopadhyay
Jan 5, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Mahesh Kandasamy
Jan 8, 2021·The Analyst·Maria Ana Cristina Huergo, Nguyen Thi Kim Thanh
Jan 5, 2021·Frontiers in Cardiovascular Medicine·Ahmad Aljohmani, Daniela Yildiz
Dec 29, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Christian BimeJoe G N Garcia
Jan 15, 2021·The Lancet. Respiratory Medicine·Rishi K GuptaUNKNOWN ISARIC4C Investigators
Dec 5, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Anissa ViveirosGavin Y Oudit
Jan 15, 2021·Genome Medicine·Anna C AschenbrennerUNKNOWN German COVID-19 Omics Initiative (DeCOI)
Jan 15, 2021·Cell Communication and Signaling : CCS·László Földvári-NagyKatalin Lenti
Jan 27, 2021·Cell·Alessandro Sette, Shane Crotty
Jan 28, 2021·JAMA Psychiatry·Katlyn NemaniDonald C Goff
Jan 28, 2021·Expert Review of Clinical Pharmacology·Esther Chamorro-de-VegaMaria Sanjurjo
Jan 5, 2021·Current Opinion in Psychiatry·Lindsay S McAlpineSerena Spudich
Dec 19, 2020·International Immunology·Toshio Hirano
Jan 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Esmé Jansen van VurenBrian H Harvey
Feb 3, 2021·Journal of Neurovirology·Joanna HellmuthMichael J Peluso
Feb 4, 2021·Genetics and Molecular Biology·Joel Henrique EllwangerJosé Artur Bogo Chies
Sep 14, 2020·The American Journal of Pathology·Joshua N Gustine, Dennis Jones
Nov 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Keng-Chang TsaiYi-Chang Su
Oct 20, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Nicolas Dauby, Emmanuel Bottieau
Dec 12, 2020·Scientific Reports·Marthe Jøntvedt JørgensenAnne Ma Dyrhol-Riise
Dec 19, 2020·Nature Medicine·Katie J EwerUNKNOWN Oxford COVID Vaccine Trial Group
Nov 17, 2020·Frontiers in Immunology·Taylon Felipe SilvaMilena Menegazzo Miranda-Sapla
Dec 5, 2020·Journal of Translational Medicine·Mathieu BlotUNKNOWN LYMPHONIE study group
Dec 29, 2020·Frontiers in Immunology·Faria AhmedSeung-Hwan Lee

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enzyme-linked immunosorbent assay
PCR
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X-ray

Software Mentioned

Epic
SQL SQL
Oracle
Epic Caboodle
SAS
Epic Clarity
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GraphPad Prism
R
tidyverse

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