An Information Theoretical Study of the Epistasis Between the CNR1 1359 G/A Polymorphism and the Taq1A and Taq1B DRD2 Polymorphisms: Assessing the Susceptibility to Cannabis Addiction in a Turkish Population

Journal of Molecular Neuroscience : MN
Aysun B IsirMuradiye Nacak

Abstract

Addiction is a complex, multi-factorial disease, and thus, analyzing genetic variants at multiple loci and gene-gene interactions among them (epistasis) can provide crucial clues about causative factors of addiction which cannot be detected with single-nucleotide polymorphism (SNP) association studies. In this study, we discuss the interaction between the 1359 G/A polymorphism of the CNR1 gene and the DRD2 gene polymorphisms and the net effect of any possible epistasis on the cannabis addiction phenotype in a Turkish population. Using bivariate synergy and mutual information concepts as a means of capturing the magnitude of interaction between marker pairs, the present study not only confirms the A1 marker allele as a risk factor but also reveals a finer-grained association between A and B markers which manifests itself both as a preventive and a risk factor. Our results indicate that the increased phenotype of cases require an individual to be either heterozygous at both loci or homozygous at locus B with homozygous risk factor A1A1 present. We hypothesize that overlapping expressions of CB1 and D2R is the cause of CB1-D2R interactions in cases of substance abuse and the different polymorphisms of CNR1 and DRD2 genes may have ...Continue Reading

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Citations

Jul 30, 2016·Scientific Reports·Yuan ChenZheming Yuan
Oct 12, 2018·Addiction Biology·Geneviève LafayeAmine Benyamina
Jan 15, 2021·Pharmacology, Biochemistry, and Behavior·Eduardo K TamuraNatalí N Guerrero-Vargas
Feb 13, 2021·Eating and Weight Disorders : EWD·Luz María GonzálezGuillermo Gervasini
Jul 25, 2021·International Journal of Molecular Sciences·Thomas MurphyBernard Le Foll

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