PMID: 7537357Feb 6, 1995Paper

An inhibitor for calcineurin, FK506, blocks induction of long-term depression in rat visual cortex

Neuroscience Letters
N ToriiT Tsumoto

Abstract

Long-term depression (LTD) of synaptic transmission, often used as an essential component in synaptic models for learning, memory and forgetting, can be produced in layer II/III of the visual cortex by a prolonged, low-frequency stimulation (LFS) of layer IV. The activation of Ca2+/calmodulin-dependent protein phosphatase, calcineurin, has been postulated to play a role in the induction of LTD. The recent introduction of a specific inhibitor for calcineurin, FK506, prompted the investigation of the involvement of this phosphatase in the induction of LTD in visual cortex. Thus, we administered FK506 at 1 microM to visual cortical slices of young rats, and found that it did not significantly affect field responses of layer II/III evoked by test stimulation of layer IV at 0.1 Hz, but prevented LTD of the responses from being induced by LFS (1 Hz for 15 min) in all the 10 slices tested. Without FK506, significant LTD was induced by the same parameters of LFS in 8 of the 12 slices. These results suggest the critical involvement of calcineurin in producing LTD in visual cortex.

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Citations

Feb 11, 1998·Molecular Neurobiology·B G Gold
Nov 19, 2003·Biochemical and Biophysical Research Communications·Isabelle M Mansuy
May 12, 2009·Nature Neuroscience·Koji YashiroBenjamin D Philpot
Jan 25, 2003·The European Journal of Neuroscience·Hiroki YasudaTadaharu Tsumoto
Feb 24, 2001·Behavioural Pharmacology·I Izquierdo, J L McGaugh
Jan 15, 2013·Neuron·Antonio Rodríguez-MorenoOle Paulsen
Jun 19, 2015·Scientific Reports·Amber Petersen, Nashaat Z Gerges
Aug 29, 2009·The EMBO Journal·Ling ZhongNashaat Z Gerges
Feb 7, 1997·Brain Research·P L Gabbott, S J Bacon
Sep 4, 2004·Molecular and Cellular Neurosciences·Vincent OssipowMarc Ballivet
Jul 14, 2006·Current Opinion in Neurobiology·Sonja B HoferMark Hübener
Jun 11, 2016·Cerebral Cortex·Yuniesky Andrade-TalaveraAntonio Rodríguez-Moreno
Feb 11, 2020·Frontiers in Molecular Neuroscience·Ling Zhong, Nashaat Z Gerges
Aug 28, 2010·Communicative & Integrative Biology·Ling Zhong, Nashaat Z Gerges
Jan 27, 2005·The Journal of Comparative Neurology·Curtis C BellJianji Y Yang
Sep 10, 2005·Brain Research·Abdulbaki AgbasElias K Michaelis

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