PMID: 3756220Oct 1, 1986Paper

An inhibitor of ornithine decarboxylase in lactogen-deprived Nb2 node rat lymphoma cells

Biochimica Et Biophysica Acta
J F RichardsP W Gout

Abstract

A previous study has shown that the activity of ornithine decarboxylase in cultured Nb2 node rat lymphoma cells falls to undetectable levels when cells become quiescent following incubation in lactogen (prolactin)-deficient medium. In the present study, it was found that addition of extracts of the lactogen-deprived, quiescent cells to extracts of log-phase cells markedly reduced the ornithine decarboxylase activity of the latter, the inhibitory activity being proportional to the amount of quiescent cell extract added. Evidence is presented that the ornithine decarboxylase-inhibitory activity in the quiescent cell extracts is due to an antizyme-like, polypeptide factor with an Mr of approx. 28,000. The activity of the inhibitor appears to be directed rather specifically against ornithine decarboxylase, since the activities of S-adenosylmethionine decarboxylase, thymidine kinase and uridine kinase were not affected. The Nb2 cell ornithine decarboxylase inhibitor may have an important role in modulating the cellular levels of ornithine decarboxylase as they change in response to the withdrawal and restoration of extracellular mitogenic lactogens.

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Citations

Jan 1, 1996·Pharmacology & Therapeutics·D A Weigent
Dec 1, 1992·Cell Biochemistry and Function·C StefanelliC M Caldarera
May 1, 1991·Molecular and Cellular Endocrinology·G ScalabrinoM E Ferioli
Aug 15, 1989·Archives of Biochemistry and Biophysics·T PengJ F Richards

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