An inhibitory gate for state transition in cortex

ELife
Stefano ZuccaTommaso Fellin

Abstract

Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale.

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Citations

Apr 26, 2019·PLoS Computational Biology·Renato Duarte, Abigail Morrison
Oct 17, 2019·Nature Reviews. Neuroscience·Antoine R AdamantidisThomas C Gent
Oct 24, 2019·Journal of Neurophysiology·A AlishbayliB Englitz
May 15, 2020·The Journal of Physiology·Maria Perez-ZabalzaMaria V Sanchez-Vives
Jul 11, 2018·Frontiers in Systems Neuroscience·Elisa C WalshPatrick L Purdon
Aug 1, 2019·Nature Methods·Abbas KazemipourKaspar Podgorski
May 13, 2020·Nature Neuroscience·Kimiya NarikiyoYoshihiro Yoshihara
May 28, 2020·Frontiers in Systems Neuroscience·John J TukkerRobert N S Sachdev
Jun 13, 2018·Nature Neuroscience·Thomas C GentAntoine R Adamantidis
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Mar 21, 2020·Neuroscience·Maria V Sanchez-VivesRamon Reig
Nov 15, 2020·Brain : a Journal of Neurology·Simone SarassoMarcello Massimini
May 22, 2021·Advanced Science·Almudena Barbero-CastilloPau Gorostiza

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Methods Mentioned

BETA
Fluorescence
transgenic

Software Mentioned

ViALUX
GraphPad Prism
Neurolucida
ALP
LabVIEW
PatchMaster
pClamp
MATLAB
OriginLAB

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