PMID: 6404502Mar 7, 1983Paper

An inhibitory role for morphine on the release of dopamine into hypophysial portal blood and on the synthesis of dopamine in tuberoinfundibular neurons

Brain Research
M J ReymondJ C Porter

Abstract

The intracerebroventricular administration of morphine to ovariectomized rats resulted in a marked decrease in the concentration of dopamine in plasma of hypophysial portal blood. A 90% reduction in the rate of release of hypothalamic dopamine into hypophysial portal blood occurred during the 60 min following the intraventricular administration of 60 ng of morphine sulfate. A dose-related decrease in the rate of release of dopamine into the portal vasculature was observed between 7.5 ng and 60 ng of morphine sulfate. Regardless of the quantity of morphine sulfate (1-500 ng) given to the animals, the concentrations of norepinephrine and epinephrine in hypophysial portal plasma and femoral arterial plasma remained unchanged. The efficacy of morphine on the release of dopamine into hypophysial portal blood was not associated with an equal efficacy of the drug on the synthesis of dopamine in tuberoinfundibular neurons, as evaluated by the accumulation of dihydroxyphenylalanine (DOPA) in the median eminence of rats given 3-hydroxybenzylhydrazine (NSD 1015). No effect of morphine was observed on DOPA accumulation in the median eminence of NSD-treated rats that had received 50 ng of morphine sulfate intracerebroventricularly, and only...Continue Reading

References

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Citations

Dec 1, 1984·Italian Journal of Neurological Sciences·A Albanese, M C Altavista
Jun 1, 1991·Aging : Clinical and Experimental Research·G P TrentiniM Criscuolo
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·C H KinsleyA L Graham
Apr 1, 1984·Psychiatry Research·A G RobertsonH Y Meltzer
Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Mar 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ana B F Emiliano, Julie L Fudge
Oct 1, 1989·Journal of Endocrinological Investigation·F CamanniE E Müller
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Jun 1, 1987·Asia-Oceania Journal of Obstetrics and Gynaecology·S Kawagoe, M Hiroi

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