PMID: 9440376Jan 24, 1998Paper

An initial assessment, using 24-h [13C]leucine kinetics, of the lysine requirement of healthy adult Indian subjects

The American Journal of Clinical Nutrition
Anura V KurpadV R Young

Abstract

The international 1985 FAO/WHO/UNU upper dietary requirement for lysine of 12 mg.kg-1.d-1 may be inadequate for healthy Indian adults. To test this, we used a modified indicator amino acid oxidation technique to assess the adequacy of lysine intake of 12 and 28 mg.kg-1.d-1. Seven healthy, male, Indian subjects were studied during each of two randomly assigned 6-d periods while receiving an otherwise adequate diet based on an L-amino acid mixture. Beginning at 1800 on day 6 of the diet, a 24-h infusion protocol in which a [13C]leucine tracer was administered intravenously was used to assess leucine oxidation and daily leucine balance at each test lysine intake. Mean 24-h leucine oxidation was 54.7 compared with 46.9 mg.kg-1.d-1 (P < 0.05) and mean 24-h leucine balances were -4.1 and 3.5 mg.kg-1.d-1 (P < 0.05) for lysine intakes of 12 and 28 mg, respectively. Leucine balances were significantly negative (0.025 < P < 0.05) with the 12-mg lysine intake and not significantly different (P > 0.10) from zero or equilibrium with the 28-mg intake. These findings indicate that the international requirement for lysine appears to be inadequate to maintain body amino acid homeostasis and function in apparently healthy subjects characteristic...Continue Reading

Citations

May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·C C MetgesV R Young
Nov 28, 2001·The American Journal of Clinical Nutrition·A V KurpadV R Young
Mar 28, 2002·The American Journal of Clinical Nutrition·Sudhir BorgonhaVernon R Young
Jul 5, 2002·The Journal of Nutrition·Anura V KurpadVernon R Young
Mar 29, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Jun 24, 2004·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Apr 30, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Apr 4, 2003·The Journal of Nutrition·Anura V Kurpad, Vernon R Young
Dec 9, 2015·Isotopes in Environmental and Health Studies·Peter JunghansAnne-Helene Tauson
Dec 12, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·V R Young, S Borgonha
May 28, 2009·European Journal of Clinical Nutrition·U S UnniA V Kurpad
Jan 21, 2019·Amino Acids·Kohsuke HayamizuMakoto Nakano
Jul 25, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Wilfredo D MansillaAnna K Shoveller
Oct 12, 1999·The American Journal of Physiology·C C MetgesV R Young
Sep 27, 2002·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Jan 16, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Cécile BosDaniel Tomé
Aug 10, 2005·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
May 3, 2001·The American Journal of Clinical Nutrition·A V KurpadV R Young
May 28, 2009·European Journal of Clinical Nutrition·P DwarkanathF Jahoor
Jul 1, 2006·Journal of Biosciences·T RajA V Kurpad
Dec 21, 2005·The Journal of Nutrition·Anura V KurpadJustin V Gnanou
Oct 2, 2020·The Journal of Nutrition·Kohsuke HayamizuMakoto Nakano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.