An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio

Clinical Nutrition ESPEN
Marija KnezMaria Glibetic

Abstract

Zinc is an essential micronutrient for humans with important physiological functions. A sensitive and specific biomarker for assessing Zn status is still needed. The major aim of this study was to examine if the changes in the content of plasma phospholipid LA, DGLA and LA: DGLA ratio can be used to efficiently predict the dietary Zn intake and plasma Zn status of humans. The study was performed on healthy human volunteers, 25-55 years of age. The dietary Zn intake was assessed using 24 h recall questionnaires. Plasma phospholipid fatty acid analysis was done by gas chromatography, and plasma analysis of minerals by atomic absorption spectrometry. Biochemical, anthropometrical and hematological parameters were assessed. No significant relationship was found between the dietary and plasma zinc status (r = 0.07; p = 0.6). There was a statistically significant correlation between DGLA and plasma Zn (r = 0.39, p = 0.00). No relationship was observed between the linoleic acid and plasma Zn, while there was a significant negative correlation between LA: DGLA ratio and plasma Zn status (r = -0.35, p = 0.01). Similarly, there were statistically significant difference in DGLA status (p = 0.004) and LA: DGLA ratio (p = 0.042) between the...Continue Reading

Citations

Aug 15, 2019·Metallomics : Integrated Biometal Science·Rebekah E T MooreFiona Larner
Apr 18, 2017·Critical Reviews in Food Science and Nutrition·Desirrê Morais DiasHércia Stampini Duarte Martino
May 27, 2021·The Journal of Nutrition·Erinn M LiongJanet C King
Jan 24, 2018·Journal of Agricultural and Food Chemistry·Marija KnezJames C R Stangoulis

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