An initial examination of the potential role of T-cell immunity in protection against feline immunodeficiency virus (FIV) infection

Vaccine
Alek M AranyosJ K Yamamoto

Abstract

The importance of vaccine-induced T-cell immunity in conferring protection with prototype and commercial FIV vaccines is still unclear. Current studies performed adoptive transfer of T cells from prototype FIV-vaccinated cats to partial-to-complete feline leukocyte antigen (FLA)-matched cats a day before either homologous FIVPet or heterologous-subtype pathogenic FIVFC1 challenge. Adoptive-transfer (A-T) conferred a protection rate of 87% (13 of 15, p < 0.001) against FIVPet using the FLA-matched T cells, whereas all 12 control cats were unprotected. Furthermore, A-T conferred protection rate of 50% (6 of 12, p<0.023) against FIVFC1 using FLA-matched T cells, whereas all 8 control cats were unprotected. Transfer of FLA-matched T and B cells demonstrated that T cells are needed to confer A-T protection. In addition, complete FLA-matching and addition of T-cell numbers > 13 × 10(6) cells were required for A-T protection against FIVFC1 strain, reported to be a highly pathogenic virus resistant to vaccine-induced neutralizing-antibodies. The addition of FLA-matched B cells alone was not protective. The poor quality of the anti-FIV T-cell immunity induced by the vaccine likely contributed to the lack of protection in an FLA-matched ...Continue Reading

References

Nov 1, 1991·AIDS Research and Human Retroviruses·J K YamamotoM B Gardner
Feb 26, 2008·Veterinary Immunology and Immunopathology·Elizabeth W UhlJanet K Yamamoto
Oct 22, 2009·The New England Journal of Medicine·Supachai Rerks-NgarmUNKNOWN MOPH-TAVEG Investigators
Mar 10, 2010·Current HIV Research·Janet K YamamotoJames K Coleman
Jan 5, 2013·The Open AIDS Journal·Missa P SanouJanet K Yamamoto
Jan 10, 2013·Annual Review of Immunology·Janice S BlumPeter Cresswell
May 25, 2013·Science·Scott G HansenLouis J Picker
Sep 25, 2014·Frontiers in Immunology·Barbara EnsoliFabrizio Ensoli
Dec 22, 2014·Annales pharmaceutiques françaises·A L de GoedeR A Gruters
Apr 7, 2015·Human Vaccines & Immunotherapeutics·Shannon R RoffJanet K Yamamoto
May 9, 2015·Molecular and Cellular Probes·Chehrazade BrickMalika Essakalli
May 23, 2015·Current Opinion in Immunology·Geetha H MylvaganamRama Rao Amara

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