An injectable nucleus pulposus implant restores compressive range of motion in the ovine disc.

Spine
Neil R MalhotraDawn M Elliott

Abstract

Investigation of injectable nucleus pulposus (NP) implant. To assess the ability of a recently developed injectable hydrogel implant to restore nondegenerative disc mechanics through support of NP functional mechanics. Although surgical intervention for low back pain is effective for some patients, treated discs undergo altered biomechanics and adjacent levels are at increased risk for accelerated degeneration. One potential treatment as an alternative to surgery for degenerated disc includes the percutaneous delivery of agents to support NP functional mechanics. The implants are delivered in a minimally invasive fashion, potentially on an outpatient basis, and do not preclude later surgical options. One of the challenges in designing such implants includes the need to match key NP mechanical behavior and mimic the role of native nondegenerate NP in spinal motion. The oxidized hyaluronic acid gelatin implant material was prepared. In vitro mechanical testing was performed in mature ovine bone-disc-bone units in 3 stages: intact, discectomy, and implantation versus sham. Tested samples were cut axially for qualitative structural observations. Discectomy increased axial range of motion (ROM) significantly compared with intact. Hy...Continue Reading

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May 27, 2014·Journal of Neurosurgery. Spine·Ganjun FengMelanie J Gupte
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