An injectable thermosensitive hydrogel self-supported by nanoparticles of PEGylated amino-modified PCL for enhanced local tumor chemotherapy.

Soft Matter
Jinxuan GuoAnjie Dong

Abstract

We synthesized amino-modified poly(ε-caprolactone) PCN-b-PEG-b-PCN (PECN) triblock copolymers and studied the contribution of the introduced amino groups to the drug delivery efficiency of PECN nanoparticles (NPs) and their injectable thermosensitive hydrogels. PECN15 with an optimal amino group content was obtained. Firstly, the hydrophobic drug paclitaxel (PTX) was loaded into PECN15 up to 5.91% and formed PTX/PECN NPs 90 nm in size and with a slightly positive charge (7.3 mV). Furthermore, the injectable PTX/PECN NPs aqueous solution (25 wt%) at ambient temperature could undergo fast gelation at 37 °C and sustainedly release PTX/PECN NPs in 10 days. More importantly, compared with our previously reported PECT NPs, the PECN NPs without an increase in toxicity could improve the cell uptake and enhance intracellular drug release by responding to the acidic environment of the endosome. Thus, the PTX/PECN NPs presented a lower IC50 of 3.14 μg mL-1 than that of the PTX/PECT NPs (7.67 μg mL-1) and free PTX (4.65 μg mL-1). Moreover, through peritumoral injection, the PTX/PECNGel showed 94.27% inhibition rate of tumor growth on day 19, higher than PTX/PECTGel (72.28%) and Taxol® (47.03%). Therefore, the PECN NPs hydrogel provided a m...Continue Reading

References

Mar 15, 2005·Biomacromolecules·Min Ji HwangByeongmoon Jeong
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yang YangQiang Zhang
May 16, 2009·Expert Opinion on Therapeutic Patents·Xiao-Jie JuLiang-Yin Chu
Mar 3, 2010·Macromolecular Bioscience·Minh Khanh Nguyen, Doo Sung Lee
Mar 20, 2010·International Journal of Pharmaceutics·Ju Young LeeMoon Suk Kim
May 1, 1985·Langmuir : the ACS Journal of Surfaces and Colloids·E D GoddardK P Ananthapadmanabhan
May 25, 2011·ACS Nano·Erin Lavik, Horst von Recum
Jun 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·You Han Bae, Kinam Park
Dec 20, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gaurav BajajYoon Yeo
Jun 13, 2012·Chemical Society Reviews·Hyo Jung MoonByeongmoon Jeong
Feb 16, 2013·Drug Discovery Today·Priyanka Agarwal, Ilva D Rupenthal
Oct 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Nov 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pingsheng HuangAnjie Dong
Jan 28, 2016·Regenerative Biomaterials·Mantosh K SinhaYadong Wang
May 4, 2016·Advanced Drug Delivery Reviews·Jennifer I HareSimon T Barry
Feb 6, 2017·Drug Delivery·Min LiuZhiwen Yang
Feb 25, 2017·Advanced Materials·Qihang SunYouqing Shen
May 5, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yiting QiaoHangxiang Wang
May 10, 2018·Biomacromolecules·Seo Hee ChangByeongmoon Jeong
Jan 27, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hongzhang DengXiaoyuan Chen
Apr 27, 2019·Journal of Biomaterials Science. Polymer Edition·Dan PengLiandong Deng
Nov 23, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Lin-Ping WuZibiao Li
Mar 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yan ZhangMeidong Lang

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Citations

Oct 8, 2020·International Journal of Molecular Sciences·György BabosTivadar Feczkó
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Parvin Sadat MirzaghavamiVahid Pirhajati Mahabadi

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Methods Mentioned

BETA
nuclear magnetic resonance
dynamic light scattering
flow cytometry
dissection
Fluorescence
dynamic
transmission electron microscopy
flow
confocal microscopy

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