An Injectable, Wound-Adapting, Self-Healing Hydrogel for Fibroblast Growth Factor 2 Delivery System in Tissue Repair Applications

Journal of Biomedical Nanotechnology
Guopu ChenJieshou Li

Abstract

Rapid wound healing is a fundamental health concern and poses a critical challenge for healthcare systems worldwide. Here, we developed an injectable, dynamic, self-healing hydrogel serving as a fibroblast growth factor 2 (FGF2) delivery system for tissue repair applications. Benzaldehyde-terminated polyethylene glycol (BAPEG) was synthesized and cross-linked with N-Succinyl-chitosan (SCS) through reversible Schiff-base reaction to form a dynamic self-healing hydrogel. Because it can be injected after gelation and self-heal into an integral part, the hydrogel could not only auto-adapt to the irregular wound surface to provide better protection but also encapsulate drugs homogeneously and implant into tissue with a less invasive strategy. As a result, the FGF2-loaded SCS/BAPEG hydrogel is able to significantly promote the process of angiogenesis, collagen deposition, and granulation tissue formation, as well as reduce inflammation. This study opens the door to self-healing hydrogels serving as a drug delivery system for tissue repair applications.

Citations

May 28, 2020·Journal of the American Heart Association·Leon M PtaszekJeremy N Ruskin
Sep 20, 2019·Journal of Materials Science. Materials in Medicine·Cheng ZhaoJianan Ren
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Caoxin TangStefanie A Sydlik
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fenbo MaBin Tang
Aug 8, 2020·Frontiers in Cell and Developmental Biology·Ayan NurkeshArman Saparov
Jun 23, 2020·Colloids and Surfaces. B, Biointerfaces·Diksha GuptaJitender Madan
Aug 11, 2021·ACS Nano·Yongping LiangBaolin Guo
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Hongyun XuanHuihua Yuan

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