Abstract
Pathological scars occur following injuries and are often considered esthetically unattractive. Several strategies have been attempted to improve these types of scars using both surgical and nonsurgical methods. The most common treatments include cryotherapy, intralesional corticosteroid injections, 5-fluorouracil, bleomycin, interferon, and verapamil. In this study, we aim to investigate the effectiveness of dermal autologous micrografts in the treatment of pathological scars resulting from burns, trauma, or any iatrogenic source. We used a new clinical practice called Rigenera Protocol to obtain autologous micrografts which were in turn injectable in the patients. A significant improvement was observed in appearance and texture of the exaggerated scars in all cases following already 4 months of autologous micrograft treatment We have also shown that these micrografts are composed of mesenchymal stem cells and in addition, histological evaluation verified restoration of the structural layers immediately below the epidermis and a horizontal realignment of collagen fibers in the papillary dermis. Our results clearly demonstrate the optimal outcomes obtained following treatment with dermal micrografts on exaggerated scars with di...Continue Reading
References
Sep 30, 2000·Clinical and Experimental Dermatology·M NovelliM G Bernengo
Feb 9, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·F D'AndreaA Baroni
Jul 27, 2002·Plastic and Reconstructive Surgery·Thomas A MustoeUNKNOWN International Advisory Panel on Scar Management
Apr 12, 2005·Nursing Standard·Kathleen Devlin-Rooney, William James
Dec 19, 2006·Journal of Cosmetic Dermatology·Keyvan NouriMaria Patricia Rivas
Jan 18, 2008·The Journal of Investigative Dermatology·William H PeranteauKenneth W Liechty
Jan 24, 2008·International Journal of Dermatology·June Hyunkyung LeeAi-Young Lee
Feb 8, 2008·Journal of Cosmetic Dermatology·Himanshu AggarwalD K Jain
Jul 30, 2009·International Journal of Molecular Medicine·Gregor M BranHaneen Sadick
Dec 6, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·John W LawrenceMatthew B Klein
Jun 7, 2012·Stem Cell Research & Therapy·Wesley M JacksonRocky S Tuan
Aug 22, 2012·Lasers in Medical Science·Gianfranco NicolettiFrancesco D'Andrea
Nov 1, 2012·Journal of Cutaneous and Aesthetic Surgery·Meenu BararaRam Chander
Jul 3, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Lin HuangAndrew Burd
Nov 1, 2013·Journal of Indian Society of Periodontology·Giorgio BrunelliFrancesco Carinci
Sep 30, 2012·Laser Therapy·D M JianuD A Chirita
Oct 3, 2014·BioMed Research International·D PiccoloS Chimenti
Oct 7, 2014·Clinical and Experimental Dermatology·C-S WuL-Y Tien
Nov 15, 2014·Archives of Plastic Surgery·Aurelia Trisliana PerdanasariPaolo Persichetti
Mar 3, 2015·Journal of Cellular Physiology·Letizia TrovatoAntonio Graziano
Mar 27, 2015·Journal of Cosmetic Dermatology·Eman ShaarawyRania M Abdel Hay
May 9, 2015·Tissue Engineering. Part B, Reviews·Francesco De FrancescoGiuseppe Andrea Ferraro
Jun 29, 2015·Clinics in Plastic Surgery·Marco KlingerFabio Caviggioli
Jul 25, 2015·Journal of Cosmetic Dermatology·Michael S LeoRaja K Sivamani
Citations
Apr 30, 2016·International Wound Journal·Marco MarcarelliAntonio Graziano
Jun 10, 2016·Journal of Cellular Physiology·Manuela MontiRuggero Rodriguez Y Baena
Feb 25, 2017·Journal of Cellular Physiology·Sawako NodaIzumi Asahina
Aug 3, 2017·International Journal of Molecular Sciences·Shiro JimiHiroyuki Ohjimi
Jun 10, 2017·Journal of Wound Care·M A BocchiottiE A Baglioni
Oct 28, 2019·Cell Death and Differentiation·Martina BalliMaurilio Sampaolesi
Jan 4, 2020·Dermatologic Therapy·Yoshiaki HorieLetizia Trovato
Jan 7, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·L TrovatoA Graziano
Oct 24, 2019·Journal of Cellular Physiology·Rafael G RuizAntonio Graziano
May 1, 2020·International Journal of Molecular Sciences·Elena Dai PrèAndrea Sbarbati
Jul 3, 2020·Medicina·Shiro JimiArman Saparov
Nov 8, 2018·Journal of Orthopaedic Surgery and Research·Marco ViganòLaura de Girolamo
Jun 22, 2017·Pharmaceuticals·Francesca VitaliRiccardo Bellazzi
Dec 31, 2019·Stem Cells International·Michele RiccioFrancesco De Francesco
May 13, 2020·Cells·Dae Hyun HaByong Seung Cho
Oct 13, 2017·Frontiers in Cell and Developmental Biology·Ruggero Rodriguez Y BaenaSaturnino M Lupi
Oct 23, 2019·Stem Cells International·Alessandro Andreone, Daan den Hollander
Sep 22, 2020·The Journal of Dermatology·Giovanni Menchini, Carlo Astarita
Oct 5, 2019·Stem Cells International·Marco Mario TresoldiGiovanni Nicoletti
Jan 11, 2019·Aesthetic Plastic Surgery·Michele RiccioFrancesco De Francesco
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Andrea MarchesiniMichele Riccio
Oct 1, 2020·Materials·Carlos R G AraújoAndré A Pelegrine
Dec 2, 2020·Healthcare·Satoshi TakagiHiroyuki Ohjimi
Jan 23, 2021·Journal of Clinical Medicine·Marco MarcarelliAntonio Graziano