An insight into the therapeutic applications of coumarin compounds and their mechanisms of action.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Sourbh Suren GargDebasis Sahu

Abstract

The coumarins are heterocyclic compounds belonging to the class of benzopyrone enriched in various plants like tonka beans. Coumarins and their derivatives exert a vast array of bioactive properties such as anticoagulant, antibacterial, anti-inflammatory, antioxidant, antitumor, antiviral, and enzyme inhibition. Higher doses of coumarin are found to be hepatotoxic however they exhibit beneficial effects by reducing the risk of cancer and other neuronal and cardiovascular ailments. Most of these effects can be attributed to their free radical scavenging effects. Coumarins such as umbelliferone, esculetin and quercetin show antioxidant properties and protect the cellular DNA from oxidative damage. The dicumarol shows anticoagulant properties by inhibiting the action of vitamin K, whereas angelmarin has been reported to be cytotoxic in pancreatic cancer. Coumarins also reduce edema and inflammation by inhibiting the prostaglandins biosynthesis. Hydroxyl aromatic substituted derivatives such as 5-hydroxycoumarin or vicinal dihydroxy coumarins have also been found to be potent anti-inflammatory agents. Some coumarins are approved by the FDA as drugs, and warfarin is one such example. It blocks the Vitamin K reductase enzyme thus dis...Continue Reading

Citations

Dec 22, 2020·ChemMedChem·Pavitra S ThackerClaudiu T Supuran
Jan 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shin-Hun JuangHsin-Yi Hung
Feb 15, 2021·Fitoterapia·Zhi XuChangli Liang
Mar 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kai ZhengZhendan He
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Sep 18, 2021·Future Medicinal Chemistry·Ivana SokolTatjana Gazivoda Kraljević
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