An Insight into the Triabin Protein Family of American Hematophagous Reduviids: Functional, Structural and Phylogenetic Analysis

Toxins
María J Hernández-VargasGerardo Corzo

Abstract

A transcriptomic analysis of the saliva of T. pallidipennis together with a short proteomic analysis were carried out to reveal novel primary structures of the lipocalin/triabin protein families in this reduviid. Although triabins share some structural characteristics to lipocalins and they are classified as in the calcyn/lipocalin superfamily, triabins differ from lipocalins in the direction of β-strands in the general conformation of the β-barrel. The triabin protein family encompasses a wide variety of proteins, which disrupt the hemostasis of warm-blooded animals. Likewise, the function of proteins classified as triabins includes proteins that are carriers of small molecules, protease inhibitors, binders of specific cell-surface receptors as well as proteins that form complexes with other macromolecules. For example, triabin and pallidipin from the saliva of T. pallidipennis are thrombin and platelet aggregation inhibitors, respectively; triplatin from T. infestans binds to thromboxane A2; and nitrophorin from Rhodnius prolixus carries nitric oxide. Therefore, based on 42 new transcriptome sequences of triabins from the salivary glands of T. pallidipennis reported at present, and on triabin sequences of other American hemat...Continue Reading

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Citations

Apr 27, 2017·Journal of Proteomics·María J Hernández-VargasGerardo Corzo
Nov 7, 2017·PloS One·Joaquin Alonso, Manuel Martinez
Sep 29, 2020·Frontiers in Cellular and Infection Microbiology·Paula Beatriz SantiagoJaime Martins Santana
Feb 3, 2020·Trends in Parasitology·Paula B SantiagoJaime M Santana
Sep 5, 2020·European Journal of Medicinal Chemistry·Clara DavoineLionel Pochet

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Software Mentioned

BEAST
MAST
Trinity assembler
MAFFT
TreeAnotator
Multiple Em for Motif Elicitation ( MEME
ProtTest
Mascot
Motif Alignment & Search Tool ( MAST )

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