An instrument assessing satisfaction with iron chelation therapy: Psychometric testing from an open-label clinical trial

Advances in Therapy
Diana RofailMaria Domenica Cappellini

Abstract

The Satisfaction with Iron Chelation Therapy (SICT) instrument was developed based on a literature review, in-depth patient and clinician interviews, and cognitive debriefing interviews. An, open-label, single arm, multicenter trial evaluating the efficacy and safety of deferasirox in patients diagnosed with transfusion-dependent iron overload, provided an opportunity to assess the psychometric measurement properties of the instrument. Psychometric analyses were performed using data at baseline from 273 patients with a range of transfusion-dependent iron overload conditions who were participating in a multinational study. Responsiveness was further evaluated for all patients who also had subsequent satisfaction domain scores collected at week 4. Baseline SICT domain scores had acceptable floor and ceiling effects and internal consistency reliability (Cronbach's alpha: 0.75-0.85). Item discriminant and item convergent validity were both excellent although one item in each analysis did not meet the specified criterion. Small to moderate correlations were observed between SICT and Short Form 36 Health Survey (SF-36) domain scores. Patients with the highest levels of serum ferritin at baseline (>3100 ng/mL) were the least satisfied...Continue Reading

References

Sep 1, 1988·Gynecologic Oncology·C J Cohen
Jan 1, 1994·Journal of Clinical Epidemiology·E F JuniperL E Griffith
Feb 3, 1998·Social Science & Medicine·J Sitzia, N Wood
Aug 4, 1998·Paediatric Nursing·A Kanneh
Dec 22, 2000·Spine·J E Ware
Mar 29, 2001·Irish Journal of Medical Science·C BlakeY M O'Meara
Oct 18, 2001·Seminars in Hematology·P J Giardina, R W Grady
Apr 9, 2002·Mayo Clinic Proceedings·Gordon H GuyattUNKNOWN Clinical Significance Consensus Meeting Group
Mar 1, 1959·Psychological Bulletin·D T CAMPBELL, D W FISKE
Dec 1, 2004·The Hematology Journal : the Official Journal of the European Haematology Association·Vasiliki AlymaraKonstantinos L Bourantas
Jul 4, 2006·Health and Quality of Life Outcomes·Adriana IsmailGeorgina L Jones
Sep 30, 2006·Health and Quality of Life Outcomes·Linda AbetzDiana Rofail
Jul 19, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Diana RofailKrista Payne

❮ Previous
Next ❯

Citations

Jun 10, 2017·Expert Review of Clinical Pharmacology·Sulaiman SultanArshad Jahangir
May 9, 2018·The Cochrane Database of Systematic Reviews·Patricia M FortinLise J Estcourt
Oct 8, 2016·The Cochrane Database of Systematic Reviews·Patricia M FortinLise J Estcourt
Sep 14, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Vassilis GoulasArgiris Symeonidis
Jun 14, 2020·Health and Quality of Life Outcomes·Xenya KantarisLynn Myers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.