An instrumented scaffold can monitor loading in the knee joint.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
John A SzivekR K Vaidyanathan

Abstract

No technique has been consistently successful in the repair of large focal defects in cartilage, particularly in older patients. Tissue-engineered cartilage grown on synthetic scaffolds with appropriate mechanical properties will provide an implant, which could be used to treat this problem. A means of monitoring loads and pressures acting on cartilage, at the defect site, will provide information needed to understand integration and survival of engineered tissues. It will also provide a means of evaluating rehabilitation protocols. A "sensate" scaffold with calibrated strain sensors attached to its surface, combined with a subminiature radio transmitter, was developed and utilized to measure loads and pressures during gait. In an animal study utilizing six dogs, peak loads of 120N and peak pressures of 11 MPa were measured during relaxed gait. Ingrowth into the scaffold characterized after 6 months in vivo indicated that it was well anchored and bone formation was continuing. Cartilage tissue formation was noted at the edges of the defect at the joint-scaffold interfaces. This suggested that native cartilage integration in future formulations of this scaffold configured with engineered cartilage will be a possibility.

References

Apr 1, 1992·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·J A SzivekF P Magee
Jul 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T D BrownR A Brand
Oct 1, 1988·Acta Orthopaedica Scandinavica·B H NelsonT D Brown
Dec 1, 1996·The Journal of Arthroplasty·J A SzivekJ B Benjamin
Nov 15, 1997·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·J A SzivekD W DeYoung
Dec 17, 1998·Journal of Biomedical Materials Research·G A BattrawP L Anderson
Feb 24, 1999·Journal of Biomedical Materials Research·G A BattrawP L Anderson
Nov 5, 1999·Clinical Orthopaedics and Related Research·D A GrandeR E Schwartz
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H A BreinanM Spector
Oct 18, 2001·Clinical Orthopaedics and Related Research·L A SolchagaA I Caplan
Oct 18, 2001·Clinical Orthopaedics and Related Research·M BrittbergL Peterson
Dec 26, 2001·Zeitschrift für Orthopädie und ihre Grenzgebiete·F MartiniC Lebherz
Jan 19, 2002·The American Journal of Sports Medicine·Lars PetersonAnders Lindahl
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C Neidlinger-WilkeR Brand
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·Meng Deng, Kathryn E Uhrich
Oct 7, 2004·Macromolecular Bioscience·Ruiyun Zhang, Peter X Ma
Feb 1, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·J A SzivekD W DeYoung

❮ Previous
Next ❯

Citations

Nov 3, 2009·Journal of Biomechanics·W C de JongG E J Langenbach
Mar 29, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·John A SzivekJohn T Ruth
Dec 4, 2008·Journal of Biomedical Materials Research. Part a·Chris P GeffreJohn A Szivek
Apr 16, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·John A SzivekKarl H Wenger
Mar 24, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·John A SzivekJordan L Smith
Jun 9, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chris P GeffreDavid S Margolis
Jan 26, 2007·Journal of Biomedical Materials Research. Part a·J A SzivekS K Williams
Oct 1, 2009·Journal of Medical Devices·Ja SzivekCp Townsend
Feb 2, 2013·Arthritis Research & Therapy·Darryl D D'LimaClifford W Colwell
Apr 4, 2012·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Darryl D D'LimaClifford W Colwell
Jul 2, 2010·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Chris P GeffreJohn A Szivek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
John A SzivekDavid S Margolis
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Chris P GeffreDavid S Margolis
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Cody L BlissJ T Ruth
Journal of Biomedical Materials Research
N M CordaroD W DeYoung
© 2022 Meta ULC. All rights reserved