An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance

European Journal of Endocrinology
Ingrid RietveldJ A M J L Janssen

Abstract

Microalbuminuria (MA) is related to cardiovascular disease both in diabetic patients and non-diabetic subjects. We investigated whether a polymorphism near the promoter region of the IGF-I gene was related to the development of MA. For this study, 1069 participants of the Rotterdam study were selected (440 participants with an abnormal glucose tolerance (AGT), 220 participants with type 2 diabetes and 254 subjects with pre-diabetes, and 595 subjects with a normal glucose tolerance (NGT). 787 subjects were carriers of the wild type IGF-I genotype (73.6%) and 282 subjects were variant carriers (26.4%) of this IGF-I gene polymorphism. Compared to subjects with NGT the risk for microalbuminuria was higher (Odds Ratio (OR): 3.1 (95% CI: 1.2-7.7); P = 0.02) in variant carriers with AGT than in carriers of the wild type of this IGF-I gene polymorphism (OR: 2.2 (95% CI: 1.2-4.0); P = 0.009). Compared with wild type carriers with AGT, the relative risk for MA was unadjusted and non-significantly increased in variant carriers with AGT (1.6; 95% CI: 0.8-2.9). However, after adjustment for possible confounding factors (age, gender, mean blood pressure, fasting insulin, fasting glucose and smoking) this risk became significant (OR: RR 2.1; ...Continue Reading

Citations

Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·David R Clemmons
Aug 8, 2015·Journal of the American Society of Nephrology : JASN·Sanaz SedaghatM Arfan Ikram
Mar 11, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Saloua AkoudadMeike W Vernooij
Jun 19, 2015·Neurology·Sanaz SedaghatM Arfan Ikram
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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