An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population

The American Journal of Cardiology
Mojgan YazdanpanahC M van Duijn

Abstract

We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction (MI). This association was assessed in 7,983 subjects of the Rotterdam Study during 14 years of follow-up. Among 345 subjects who developed a MI, the risk of mortality was 1.49 times higher in the variant carriers of the IGF-I promoter polymorphism than in the nonvariant carriers (95% confidence interval 1.10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI.

Citations

Apr 12, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yusuke HigashiPatrice Delafontaine
Nov 23, 2007·International Immunology·Bernadett BlaskóGudmundur Jóhann Arason
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Jan 15, 2010·Trends in Endocrinology and Metabolism : TEM·Yusuke HigashiPatrice Delafontaine
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