May 20, 1999

An insulin sensitizer improves the free radical defense system potential and insulin sensitivity in high fructose-fed rats

P FaureSerge Halimi


Recently there has been growing interest in the effects of antioxidants on insulin activity. In the present study, we investigated the effect of metformin on free radical activity and insulin sensitivity in high fructose-fed rats, a diet that leads to insulin resistance. The animals were divided into four groups (n = 16 per group; experiment duration = 6 weeks): the control (C) group received a standard diet; the control metformin (CM) group was fed a control diet and received metformin (200 mg x kg(-1) x day(-1) in water); the fructose control (FT) group was fed a diet in which fructose composed 56.8% of the total carbohydrates; and the fructose metformin (FM) group received high-fructose diet and metformin (200 mg x kg(-1) x day(-1) in water). The glucose clamp technique was used to determine insulin sensitivity in eight animals per group. Metabolic and oxidative stress parameters were measured in the remaining rats. In the FT rats, insulin resistance, lower red cell CuZn superoxide dismutase activity and lower blood reduced glutathione were observed. Metformin treatment improved both the insulin activity and the antioxidant defense system. In the CM group, metformin had no effect on metabolic parameters, but improved red cel...Continue Reading

  • References
  • Citations91


  • We're still populating references for this paper, please check back later.
  • References
  • Citations91

Mentioned in this Paper

Metabolic Process, Cellular
Carbohydrate nutrients
Insulin Sensitivity
Dietary Carbohydrates
Cutaneous Mastocytosis

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Related Papers

Asia Pacific Journal of Clinical Nutrition
Srinivasan Srividhya, Carani Venkatraman Anuradha
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
G BaretA Géloën
© 2020 Meta ULC. All rights reserved