An intact facet capsular ligament modulates behavioral sensitivity and spinal glial activation produced by cervical facet joint tension

Spine
Beth A Winkelstein, Diana G Santos

Abstract

In vivo experiments using a rat model of painful facet joint distraction. To determine whether tension of the facet capsular ligament is requisite for producing pain for joint loading and to define effects on spinal glial activation. Cervical facet joint loading may initiate pain for certain conditions. While facet capsule tension has been proposed as requisite for pain, this hypothesis has not been tested. Using an established rat model of painful C6-C7 distraction, tension was applied after transection of the left facet capsule; the right capsule remained intact. Each rat (n = 8) received the same distraction simultaneously applied across both the intact and cut capsules. Sham procedures were performed on separate rats (n = 4) with no joint distraction. Bilateral forepaw mechanical allodynia was measured as a pain outcome. Cervical spinal cord tissue (C7) was harvested on day 7 to detect glial reactivity using immunohistochemistry. Distraction mechanics were consistent with conditions eliciting persistent behavioral hypersensitivity. Allodynia was produced for an intact capsule and was significantly elevated over both the cut capsule (P < 0.004) and sham (P < 0.002). Transecting the capsule before distraction did not produce ...Continue Reading

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Citations

Sep 30, 2010·Medical & Biological Engineering & Computing·Steven G Storvik, Brian D Stemper
Oct 25, 2011·Spine·Nikolai Bogduk
Oct 25, 2011·Spine·Michele CuratoloBeth A Winkelstein
Aug 10, 2011·Journal of Biomechanical Engineering·Nicolas V JaumardBeth A Winkelstein
Jan 7, 2014·The Journal of Pain : Official Journal of the American Pain Society·Christine L Weisshaar, Beth A Winkelstein
Oct 8, 2013·The Journal of Pain : Official Journal of the American Pain Society·Ling DongBeth A Winkelstein
Oct 22, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ashley Dean SmithMichele Sterling
Dec 15, 2015·Postgraduate Medicine·Laxmaiah ManchikantiMark V Boswell
Jan 30, 2013·Journal of Forensic and Legal Medicine·Charles G Davis
Mar 31, 2009·The Journal of Pain : Official Journal of the American Pain Society·Kathryn E Lee, Beth A Winkelstein
Apr 29, 2015·Clinical Orthopaedics and Related Research·Martha E ZeemanBeth A Winkelstein
May 9, 2015·Physical Medicine and Rehabilitation Clinics of North America·Richard SeroussiAdrielle Fry
Aug 3, 2013·Journal of Korean Neurosurgical Society·Seung Man HaDong Ah Shin
Jun 18, 2017·The Journal of Orthopaedic and Sports Physical Therapy·Meagan E ItaBeth A Winkelstein
Oct 21, 2014·The Open Orthopaedics Journal·Danielle SteilenSarah Sawyer
Mar 25, 2021·Global Spine Journal·Brian A KaramianGregory D Schroeder

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