PMID: 2491939Jan 1, 1989Paper

An integrated analysis of glucose, fat, and protein metabolism in severely traumatized patients. Studies in the basal state and the response to total parenteral nutrition

Annals of Surgery
J H Shaw, R R Wolfe

Abstract

A series of isotopic infusions were performed in 43 severely ill patients suffering from blunt trauma (mean injury severity score of 31). The patient data have been compared with data obtained from 32 normal volunteers, and in addition the metabolic response of the trauma patient to total nutritional support (TPN) has been assessed. The rate of VO2 was elevated in the trauma patients compared with that of the volunteers (160 mumol/kg/minute vs. 103 mumol/kg/minute). Glucose production was significantly increased in the patients compared with the volunteers (21 +/- 2 mumol/kg/minute vs. 14 +/- 1 mumol/kg/minute), but the trauma patients had an impaired capacity to directly oxidize plasma glucose. The percentage of glucose uptake oxidized in the volunteers was 36 +/- 2%, and the percentage of glucose uptake recycled was 10 +/- 1%. By contrast, in the trauma patients, 23 +/- 4% of the glucose uptake was directly oxidized, and 29 +/- 11% was recycled. The rate of glycerol turnover in the trauma patients (5.3 +/- 0.3 mumol/kg/minute) was significantly elevated compared with the volunteer value (2.2 +/- 0.1 mumol/kg/minute), and the basal rate of fat oxidation was twice as high in the patients as in the volunteers (2 mg/kg/minute vs....Continue Reading

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Citations

Mar 8, 2002·Nutrition·Roland N DickersonRex O Brown
Mar 1, 1992·Annals of Surgery·J B Koea, J H Shaw
Jun 23, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Philip F StahelErnest E Moore
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Zdenek RusavyIan A Macdonald
Oct 26, 2007·Critical Care : the Official Journal of the Critical Care Forum·Sharmila DissanaikeGrant E O'Keefe
Aug 2, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Federico Bozzetti
Sep 10, 2010·Medical Hypotheses·Shih-Ping ChengChien-Liang Liu
Oct 15, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Roland N DickersonRex O Brown
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Laurie M MorganGayle Minard
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jong O LeeDavid N Herndon
May 1, 2005·Cognitive Neuropsychology·Natalie SebanzWolfgang Prinz
Aug 1, 1992·The Proceedings of the Nutrition Society·S F Lowry
Mar 1, 1990·The British Journal of Surgery·R G Douglas, J H Shaw
Feb 1, 1989·The British Journal of Surgery·R G Douglas, J H Shaw
Dec 24, 1997·JPEN. Journal of Parenteral and Enteral Nutrition·D C FrankenfieldR N Cooney
Jul 14, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·R L SheridanR G Tompkins
Sep 29, 1998·Critical Care Medicine·B R Bistrian, T Babineau
Aug 6, 1998·The British Journal of Surgery·A G Hill, G L Hill
Jun 26, 1999·The British Journal of Surgery·M SaeedM H Irving
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J Webber
Oct 31, 2001·The American Journal of Clinical Nutrition·J A Coss-BuL S Jefferson
Feb 18, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Roland N Dickerson
Nov 11, 2005·Chronic Respiratory Disease·P J Scalise, J J Votto
May 9, 2012·International Journal of Experimental Pathology·Milan Holecek
Sep 26, 2012·The Journal of Trauma and Acute Care Surgery·Roland N DickersonRex O Brown
Jun 1, 2013·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·D D Yeh, G C Velmahos
Jun 1, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas Schricker
Apr 8, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Roland N DickersonCraig J McClain
Jan 15, 2019·International Journal of Experimental Pathology·Milan Holeček, Melita Vodeničarovová
Aug 17, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Amy K WiseKeith R Miller
Jun 2, 2020·Journal of Diabetes Science and Technology·Jennifer J OrmsbeeJ Geoffrey Chase
Mar 1, 1996·The Journal of Trauma·C L LongW S Blakemore
May 8, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T SchrickerM Georgieff
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·T SchrickerF Carli
Oct 3, 2002·Anesthesiology·Thomas SchrickerFranco Carli

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