An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer.

British Journal of Cancer
Koichiro HarukiShuji Ogino

Abstract

Histological lymphocytic reaction is regarded as an independent prognostic marker in colorectal cancer. Considering the lack of adequate statistical power, adjustment for selection bias and comprehensive tumour molecular data in most previous studies, we investigated the strengths of the prognostic associations of lymphocytic reaction in colorectal carcinoma by utilising an integrative database of two prospective cohort studies. We examined Crohn's-like reaction, intratumoural periglandular reaction, peritumoural reaction and tumour-infiltrating lymphocytes in 1465 colorectal carcinoma cases. Using covariate data of 4420 colorectal cancer cases in total, inverse probability-weighted Cox proportional hazard regression model was used to control for selection bias (due to tissue availability) and potential confounders, including stage, MSI status, LINE-1 methylation, PTGS2 and CTNNB1 expression, KRAS, BRAF and PIK3CA mutations, and tumour neoantigen load. Higher levels of each lymphocytic reaction component were associated with better colorectal cancer-specific survival (Ptrend < 0.002). Compared with cases with negative/low intratumoural periglandular reaction, multivariable-adjusted HRs were 0.55 (95% CI, 0.42-0.71) in cases wit...Continue Reading

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Citations

Oct 8, 2020·Cancer Immunology Research·Juha P VäyrynenJonathan A Nowak
May 2, 2021·Journal for Immunotherapy of Cancer·Juha P VäyrynenJonathan A Nowak
Feb 27, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer BorowskyShuji Ogino
May 26, 2021·European Journal of Gastroenterology & Hepatology·David MansouriUNKNOWN Integrated Technologies for Improved Polyp Surveillance (INCISE) collaborators
Jul 16, 2021·Journal of the National Cancer Institute·Tomotaka UgaiShuji Ogino

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Methods Mentioned

BETA
surgical resection

Software Mentioned

POLYSOLVER
NetMHCpan
SAS

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