An integrated approach to methicillin-resistant Staphylococcus aureus control in a rural, regional-referral healthcare setting

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
William A BowlerChristine Fernandez

Abstract

To curtail the prevalence and cross-transmission of methicillin-resistant Staphylococcus aureus (MRSA) in a rural healthcare setting. Before-after, quasi-experimental quality improvement study. A regional-referral hospital, 5 affiliated nursing homes, and an outpatient MRSA clinic. Residents of the 5 nursing homes were screened for MRSA at baseline and 1 year later. Active surveillance cultures were performed on subsequently admitted nursing home residents, "high-risk" patients admitted to the hospital, and household contacts of clinic patients. The decolonization regimen consisted of systemic therapy with minocycline and rifampin and topical therapy with nasal mupirocin ointment and 5% tea tree oil body wash. Three separate samples for cultures to document clearance of MRSA colonization were obtained at 1-week intervals 1 month after the completion of decolonization therapy. Samples for follow-up cultures were obtained at month 6 and month 12 after the completion of decolonization therapy. After intervention and follow-up for 12 months or more, the prevalence of MRSA carriage at the nursing homes decreased by 67% (P < .001), and 120 (82%) of 147 nursing home residents and 111 (89%) of 125 clinic patients remained culture-negat...Continue Reading

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Aug 8, 2021·Infectious Disease Clinics of North America·Lisa SturmMarco Cassone

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